简化调强技术在鼻咽癌外照射中应用的剂量学研究

发布时间：2018-02-04 14:15

本文关键词： 鼻咽癌放射疗法简单调强放射治疗剂量学　出处：《中国癌症杂志》2015年12期 　论文类型：期刊论文

【摘要】：背景与目的:放射治疗是治疗鼻咽癌的首选方法。该文旨在研究简化调强放射治疗(simplified intensity-modulated radiation therapy,sIMRT)与调强放疗(intensity-modulated radiation therapy,IMRT)技术在鼻咽癌(nasopharyngeal carcinoma,NPC)放射治疗中的剂量学差异。方法:对10例NPC患者以相同处方剂量和目标条件分别设计9野IMRT和sIMRT计划,比较两种计划靶区剂量分布和剂量适形指数(conformity index,CI)与均匀性指数(homogeneity index,HI),不同危及器官(organ at risk,OAR)剂量参数、机器总跳数(MU)和总子野数。结果:IMRT和s IMRT的CI、HI分别为0.647、0.057和0.633、0.071(t=2.14,P=0.062;t=-6.21,P=0.000),sIMRT计划的靶区均匀性略差于IMRT,但两种治疗计划均能满足临床剂量学的要求。两种计划中各OAR剂量参数差异无统计学意义(t=-0.51~2.22,P=0.053~0.621)。sIMRT计划的机器总跳数和总子野数均少于IMRT计划。结论:鼻咽癌sIMRT计划的靶区剂量覆盖与IMRT计划相当,均匀性略差于IMRT;危及器官受照剂量相当,但sIMRT技术可显著减少机器总跳数和总子野数,对患者数量大的治疗中心提高治疗效率具有较高的优势。
[Abstract]:Background and objective: radiotherapy is the preferred method for the treatment of nasopharyngeal carcinoma. This paper aims to study the simplified intensity-modulated radiotherapy (simplified intensity-modulated radiation therapy, sIMRT) and intensity-modulated radiotherapy (intensity-modulated radiation therapy IMRT (nasopharyngeal) in nasopharyngeal carcinoma carcinoma, NPC) dosimetric differences in radiotherapy. Methods: 10 cases of NPC patients at the same dosage and target conditions were designed 9 Wild IMRT and sIMRT plan, two plan dose distribution and dose conformal index (conformity, index, CI) and evenness index (homogeneity, index, HI) in different organs (organ at, risk, OAR) dose parameters, total mus (MU) and the total number of segments. Results: IMRT and s IMRT CI, HI 0.647,0.057 and 0.633,0.071 respectively (t=2.14, P=0.062; t=-6.21, P=0.000), sIMRT plans to target the uniformity of slightly less than IMRT, but the two The treatment plan can meet the requirements of clinical dosimetry. No statistically significant difference in dose parameters of each OAR two programs (t=-0.51~2.22, P=0.053~0.621).SIMRT plan total mus and the total number of segments were less than IMRT. Conclusion: the NPC sIMRT plan target dose coverage and IMRT plan is less uniform in IMRT; the dose of organs at risk, but the sIMRT technology can significantly reduce machine total hops and the total number of segments, the number of patients with high large treatment center to improve the treatment efficiency advantage.

【作者单位】：复旦大学附属肿瘤医院放射治疗科复旦大学上海医学院肿瘤学系;
【分类号】：R739.63;R730.55
【正文快照】： 鼻咽癌是我国最常见的恶性肿瘤之一,有研究显示,放射治疗是目前治疗鼻咽癌的首选治疗手段[1]。调强放疗(intensity-modulatedradiation therapy,IMRT)技术是在三维适形放疗技术的基础上发展起来的一种放疗技术,它克服了三维适形技术的局限,可实现靶区处方剂量的进一步提高和危

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