系统毒理学——法医毒物学发展的机遇与挑战

发布时间：2018-02-26 12:31

本文关键词： 法医毒物学系统毒理学组学基因组学蛋白组学代谢组学　出处：《中国司法鉴定》2016年05期 　论文类型：期刊论文

【摘要】：随着生命科学新理论和新技术的发展和渗透,形成了基于基因组学、蛋白组学和代谢组学等组学技术的系统毒理学,赋予法医毒物学新的研究平台,使之从研究思路、方法和理念发生了根本性转变。综述了组学技术及其在法医毒物学领域的研究进展,以及组学技术发展和应用亟待突破的方法标准化、组学数据库和多组学信息集成等关键问题,提出法医毒物学研究应更加注重人群研究和应用价值。系统毒理学有望在探索毒物代谢酶的基因多态性与毒物代谢规律之间的关系、阐明毒物对机体毒性作用和机制、寻找中毒相关生物标志物,以及确定毒性剂量阈值等方面取得突破,是法医毒物学未来发展的机遇与挑战。
[Abstract]:With the development and penetration of new theories and technologies in life sciences, systematic toxicology based on genomics, proteomics and metabonomics has been formed, and a new research platform for forensic toxicology has been given. The methods and ideas have been fundamentally changed. This paper reviews the advances in the field of forensic toxicology and the standardization of methods for the development and application of cluster techniques. It is suggested that forensic toxicology research should pay more attention to the value of population research and application. Systematic toxicology is expected to explore the relationship between gene polymorphism of toxic metabolites and the regularity of toxic metabolism. It is an opportunity and challenge for the future development of forensic toxicology to clarify the toxic effect and mechanism of toxicology, to find out the biomarkers related to poisoning, and to determine the threshold of toxic dose.
【作者单位】：司法部司法鉴定科学技术研究所上海市法医学重点实验室上海市司法鉴定专业技术服务平台;
【基金】：上海市科技攻关项目(15DZ1207500) 上海市法医学重点实验室资助项目(14DZ2270800) 上海市司法鉴定专业技术服务平台资助项目(16DZ2290900)
【分类号】：D919

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