喉癌CT灌注参数与血管内皮生长因子表达的相关性研究

发布时间：2018-03-02 15:43

  本文选题：喉癌　切入点：CT灌注参数　出处：《中华全科医学》2016年03期 　论文类型：期刊论文

【摘要】：目的探讨喉癌CT灌注参数与血管内皮生长因子(VEGF)表达的相关性及其在喉癌临床诊治中的应用价值。方法选取经临床活检证实的喉癌病例23例,行术前CT灌注检查并计算各灌注参数(BF、BV、MTT、PS)值,术后取病变组织行病理学检查证实并行免疫组化染色,检测其VEGF积分。应用SPSS 13.0统计软件包分别对喉癌组织和正常肌肉组CT灌注参数以及喉癌组织CT灌注参数和喉癌术后组织血管内皮生长因子积分进行统计学处理,统计分析各CT灌注参数值与VEGF积分的相关性。结果喉癌组织和相应区域正常肌肉间各灌注参数BF值、BV值、MTT值及PS值均存在显著性差异,喉癌的灌注参数明显高于正常肌肉(P0.05)。喉癌的灌注参数的BF值和BV值与其VEGF积分呈正相关(r=0.502,0.327,P0.05),MTT值与其VEGF积分呈负相关(r=-0.511,P0.05),而PS值与其VEGF积分无相关性(r=0.275,P0.05)。结论喉癌CT灌注参数BV、BF值与其VEGF积分具有明显的相关性,可以在一定程度上反映肿瘤的血供情况,术前通过CT灌注成像观察其参数值可以明显提高术前喉癌检查的准确性以及对指导临床抗肿瘤血管生成治疗有重要的意义,具有较高的临床应用价值。
[Abstract]:Objective to investigate the correlation between CT perfusion parameters and expression of vascular endothelial growth factor (VEGF) in laryngeal carcinoma and its value in diagnosis and treatment of laryngeal carcinoma. Methods 23 cases of laryngeal carcinoma confirmed by clinical biopsy were selected. Preoperative CT perfusion examination was performed, and the values of BFV BV MTT PSV were calculated. Pathological examination and immunohistochemical staining were performed on the pathological tissues after operation. The VEGF score was measured. The CT perfusion parameters of laryngeal carcinoma tissue and normal muscle group, the CT perfusion parameters of laryngeal carcinoma tissue and vascular endothelial growth factor score after laryngeal cancer operation were statistically analyzed by SPSS 13.0 statistical software package. Results there were significant differences in BF value and BV value and PS value between laryngeal carcinoma tissues and normal muscles. The perfusion parameters of laryngeal carcinoma were significantly higher than that of normal muscle carcinoma P0.05.The BF and BV values of laryngeal carcinoma were positively correlated with their VEGF scores. There was a negative correlation between VEGF value and VEGF score, but there was no correlation between PS value and VEGF score. Conclusion CT perfusion of laryngeal carcinoma has no correlation with VEGF score. There is a significant correlation between the VEGF integral and the BF value of the parameter. It can reflect the blood supply of the tumor to a certain extent. Observing the parameters by CT perfusion imaging before operation can obviously improve the accuracy of preoperative examination of laryngeal carcinoma and have important significance in guiding clinical anti-tumor angiogenesis therapy. It has high clinical application value.
【作者单位】： 杭州师范大学附属医院影像科;杭州师范大学附属医院耳鼻咽喉科;杭州师范大学附属医院病理科;浙江大学医学院附属邵逸夫医院放射科;
【基金】：浙江省自然科学基金项目(Y2100578) 浙江省医药卫生一般研究计划项目(2011KYB068) 浙江省医学会临床科研基金项目(2011ZYC-A33) 杭州市卫生科技计划一般(A)类项目(2011A018)
【分类号】：R739.65;R730.44
，

本文编号：1557138