肱骨短小症患者临床体征与骨骼X线改变特征分析

发布时间：2018-03-04 07:38

本文选题：骨软骨病　切入点：骨发育不良　出处：《中国地方病防治杂志》2015年01期 　论文类型：期刊论文

【摘要】：目的分析肱骨短小症患者的体征和X线征;方法依据临床检查和X光拍片,分析确认该病的临床体征和X线病变特征;结果该病的突出特征是肱骨短小,上臂与前臂长度不成比例,两者比值在0.45-0.65之间,远小于两个对照组(F=352.34,P0.001);多数患者身材矮小,个别患者身高基本正常;患者肘弯明显;走路姿势呈蹒跚步态;体格发育较差;心血管系统正常,智力发育正常;该病患无论临床检查还是X线检查,其手指骨没有病变或极其轻微,这是与大骨节病的主要区别;患者X线改变明显,主要集中在肱骨上,主要表现为骨端粗大变形,骨发育不良,长管状骨的骨端呈现为"干骺连续征",这具有鉴别诊断的意义;结论本病属于骨软骨发育不良类疾病,与目前已知的骨病有明显不同,目前,课题组正在做遗传基因分析,或为一新发现的特殊骨病,但尚需排除是大骨节病的一个特殊类型。
[Abstract]:Objective to analyze the signs and X-ray signs of short humerus patients. Methods according to the clinical examination and X-ray radiography, the clinical signs and X-ray pathological features of the disease were analyzed and confirmed. Results the prominent feature of the disease was short humerus. The ratio of the length of upper arm to forearm was between 0.45-0.65, which was much smaller than that of the two control groups (P 0.001). Most of the patients were short, and the height of individual patients was normal, the elbow curve was obvious, the walking posture was stumbling, the physical development was poor, and the length of the upper arm was not proportional to that of the forearm, the ratio was 0.45-0.65, which was far less than that of the two control groups. The cardiovascular system is normal and the mental development is normal. The patient's finger bone has no lesions or is extremely mild, regardless of clinical or X-ray examination, which is the main difference from Kaschin-Beck disease. The X-ray changes of the patient are obvious and mainly concentrated on the humerus. The main manifestations are gross deformation of bone end, dysplasia of bone, and continuous metaphyseal sign of bone end of long tubular bone, which is of significance in differential diagnosis. Conclusion this disease belongs to osteochondral dysplasia and is obviously different from known bone diseases. At present, the research group is doing genetic analysis, or is a new special bone disease, but still need to exclude is a special type of Kaschin-Beck disease.
【作者单位】：泰山医学院流行病学研究所;西藏自治区地方病防治研究所;
【基金】：国家自然科学基金(81060228;81273155) 山东省自然科学基金(ZR2012HL47)
【分类号】：R681;R816.8

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