等渗低浓度碘对比剂对兔脑CT灌注参数的影响

发布时间：2018-03-10 08:30

本文选题：脑　切入点：对比剂　出处：《中国医学影像技术》2016年06期 　论文类型：期刊论文

【摘要】：目的探讨采用等渗低浓度碘对比剂碘克沙醇(270mgI/ml)对兔脑CT灌注参数的影响。方法将50只健康成年雄性新西兰大白兔随机均分为A组(碘海醇350mgI/ml)和B组(碘克沙醇270mgI/ml)。对两组实验兔行256层螺旋CT脑灌注扫描,由2名阅片者于CT图像后处理工作站获取脑灌注的脑血流量(CBF)、脑血容量(CBV)、平均通过时间(MTT)、达峰时间(TTP)、毛细血管通透率和灌注参数图,分析上矢状窦CT值、CNR和脑组织的SNR,按照4分法评价各组图像质量,采用两独立样本t检验和Mann-Whitney U检验对两组结果进行统计学分析。结果共36只兔脑CT灌注扫描成功,A组20只,B组16只。两组兔CT脑灌注的灌注参数值CBF、CBV、MTT、TTP差异均无统计学意义(P均0.05),A组的毛细血管通透率高于B组,差异有统计学意义(P0.05),两组的上矢状窦CT值和CNR、脑组织的SNR差异均无统计学意义(P0.05),两组的图像质量主观评分差异无统计学意义(P0.05),2名阅片者对图像评价的一致性良好(Kappa=0.419,P0.01)。结论在相同扫描参数条件下,采用低浓度对比剂兔脑CT灌注成像与常规浓度对比剂相比,图像质量和灌注参数(除毛细血管通透率)均不受影响。
[Abstract]:Objective to investigate the effect of iodoxacin 270 mg I / ml on cerebral CT perfusion parameters in rabbits. Methods 50 healthy adult New Zealand white rabbits were randomly divided into two groups: group A (350 mg / ml) and group B (270 mg / ml). Two groups of experimental rabbits were scanned with 256-slice spiral CT. The cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), peak time (TTP), capillary permeability and perfusion parameters were obtained from two radiographs on the CT image postprocessing workstation. The CT value of superior sagittal sinus and the SNR of brain tissue were analyzed, and the image quality of each group was evaluated according to the 4-score method. Two independent samples t test and Mann-Whitney U test were used to analyze the results of the two groups. Results A group of 20 rabbits were successfully scanned by CT perfusion and 16 from group B. There was no significant difference in cerebral perfusion parameters between the two groups. The capillary permeability of group A was higher than that of group B. There was no significant difference in CT value of superior sagittal sinus and SNR in brain tissue between the two groups (P 0.05). There was no significant difference in subjective score of image quality between the two groups. There was no significant difference in subjective score of image quality between the two groups. Conclusion under the condition of the same scanning parameters, The image quality and perfusion parameters (except capillary permeability) of rabbit brain with low concentration contrast agent were not affected compared with conventional concentration contrast agent.
【作者单位】：第二军医大学附属长征医院影像医学与核医学科;飞利浦中国影像研究学院;GE医疗集团生命科学事业部;
【分类号】：R816.1

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