基于IMRT和VMAT的自适应优化算法的研究与应用

发布时间：2018-03-16 07:13

本文选题：调强放射治疗　切入点：容积弧形调强治疗　出处：《上海交通大学》2013年硕士论文　论文类型：学位论文

【摘要】：调强放射治疗（Intensity Modality Radiation Therapy, IMRT）和容积弧形调强治疗（Volumetric ModalityArc Therapy，VMAT）是目前放射治疗中所采用的主流技术。论文通过对IMRT、VMAT、及采用该两项技术的放射治疗方案在临床中应用现状的分析，针对IMRT和VMAT在放射治疗中所存在的不足，提出了一种基于IMRT和VMAT的自适应优化算法（Adaptive Optimization Program，AOP）。通过对采用该算法的放射治疗方案在仿真人体模上的实验和实验结果的分析，验证其在临床上的可行性和可推广性。论文的研究工作主要有以下几个方面： 1.通过对IMRT和VMAT技术的分析，指出其在放射治疗中所存在的不足。IMRT治疗复杂、每个照射野上附带子野过多、放疗机执行时间长、效率低、缺乏人性化的考虑；VMAT治疗速度快效率高，但在放疗方案的优化中具妥协性、过多的全身照射范围使病人体部低剂量照射区域大。 2.针对IMRT和VMAT在放射治疗中所存在的不足，，通过对放射治疗方案在临床中应用现状的分析，提出一种基于IMRT和VMAT的优化算法。采用该算法的放射治疗方案既保留了高精度，又具有较高的效率，且总子野数少于IMRT/VMAT。 3.对采用AOP的放射治疗方案在仿真人体模上进行仿真实验：在仿真人体模头颈部、腹部肿瘤的虚拟病例下测试成功，符合临床要求。 4.通过对仿真实验及其实验结果的分析，验证该算法在临床上的可行性与实用性。本文提出的AOP及采用该算法的放射治疗方案在仿真环境下得到了较好的临床实验效果。实验结果表明AOP在仿真人体模上有临床可实现性且具备向临床推广的可能性。
[Abstract]:Intensity Modality Radiation Therapy (IMRT) and volume intensity modulated intensity modulated ModalityArc (VRT) are the main techniques used in radiotherapy at present. In view of the shortcomings of IMRT and VMAT in radiotherapy, an adaptive Optimization program AOPO algorithm based on IMRT and VMAT is proposed. The experimental results and experimental results of radiation therapy schemes based on this algorithm in simulated human models are analyzed. To verify its clinical feasibility and extensibility. The research work of this paper mainly includes the following aspects:. 1. Through the analysis of IMRT and VMAT technology, it is pointed out that the shortcomings of IMRT and VMAT in radiotherapy are complex. Each irradiation field has too many sub-fields, the time of radiotherapy machine is long, and the efficiency of radiotherapy machine is low. In the absence of humanized consideration, VMAT treatment is fast and efficient, but it is compromise in the optimization of radiotherapy scheme, too much whole body irradiation range makes the low dose irradiation area of patient's body larger. 2. In view of the deficiency of IMRT and VMAT in radiotherapy, an optimization algorithm based on IMRT and VMAT is proposed by analyzing the present situation of clinical application of radiotherapy. It also has high efficiency, and the total number of subfields is less than IMRT / VMATT. 3. The emulation experiment was carried out on the simulated human model with the radiation therapy scheme of AOP: the virtual cases of head and neck and abdominal tumors were successfully tested, which met the clinical requirements. 4. The simulation experiment and its results are analyzed. The feasibility and practicability of the algorithm in clinic are verified. The proposed AOP and the radiation therapy scheme using the algorithm have achieved good clinical experimental results in the simulation environment. The experimental results show that AOP is applied in the simulation of human model. It has clinical realizability and the possibility of popularizing to clinic.
【学位授予单位】：上海交通大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R730.55;TP301.6

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