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金匮肾气丸和运动对中老龄大鼠脂代谢影响的实验研究

发布时间:2018-03-24 19:45

  本文选题:金匮肾气丸 切入点:运动 出处:《曲阜师范大学》2012年硕士论文


【摘要】:1研究目的 探讨金匮肾气丸和运动对中老龄雌性大鼠脂代谢的影响,以期为调节中老年女性脂代谢紊乱找出科学合理的干预方法和理论依据。 2研究方法 选取雌性12月龄wistar大鼠80只,将大鼠按体重随机分为八大组,即对照组(A)、服药组(B)、20min运动组(C1)、40min运动组(C2)、60min运动组(C3)、服药20min运动组(D1)、服药40min运动组(D2)和服药60min运动组(D3)。8周服药和跑台运动训练后,取血测血清胆固醇(TC)、甘油三酯(TG)和高、低密度脂蛋白胆固醇(HDL-C、LDL-C)的含量以及血清脂蛋白脂酶(LPL)和肝脂酶(HL)的活性。所有数据用SPSS17.0软件进行统计学处理。 3实验结果 与对照组比较,服药组血中TC、TG、LDL-C明显降低,而HDL-C显著升高(P<0.O5),而运动对血清TC和HDL-C无显著差异;40min、60min运动组血中TG明显降低(P<0.O5),而服药40min和60min运动组TG非常显著降低(P<0.O1),并且显著低于单纯服药组和40min、60min运动组(P<0.O5);40min运动组血中LDL-C显著降低(P<0.O5),而服药40min运动组LDL-C非常显著降低(P<0.O1),并且显著低于单纯服药组和40min运动组(P<0.O5);与对照组比较,服药组和40min运动组血中LPL活性显著升高(P<0.O5),服药40min运动组血LPL活性非常显著升高(P<0.O1),并且显著高于服药组和40min运动组(P<0.O5);与对照组相比,服药组和其它各组血HL活性均无显著影响作用。 4结论 4.1单纯的服用金匮肾气丸能显著抑制中老龄大鼠血中TC、TG、LDL-C含量的上升,促进HDL-C含量以及LPL活性的升高,提示金匮肾气丸具有一定的调节脂代谢的作用。 4.2运动能够显著降低中老龄大鼠血中TG、LDL-C含量以及升高LPL活性,,提示适宜量的运动能够改善中老龄大鼠的脂代谢紊乱。 4.3服用金匮肾气丸与运动相结合对降低中老龄大鼠血中TG、LDL-C水平以及提高LPL活性有非常显著的作用,且效果优于单纯服药和运动,提示服用金匮肾气丸结合运动对调节中老龄大鼠脂代谢有很好的作用。
[Abstract]:1 purpose of research. To explore the effect of Jinkui Shenqi pills and exercise on lipid metabolism in middle-aged and aged female rats in order to find scientific and reasonable intervention methods and theoretical basis for regulating lipid metabolism disorder of middle-aged and aged women. 2 research methods. Eighty female 12-month-old wistar rats were randomly divided into eight groups according to their body weight. In the control group, C _ (1) and C _ (1), C _ (1) and C _ (3), C _ (3) and C _ (3), C _ (3), C _ (3), C _ (3), C _ (2), C _ (2), C _ (1), C _ (1), C _ (1), C _ (1), C _ (1), C _ (1), C _ (1), C _ (1), C _ (1), C _ (1), C _ (1), C _ (1), C _ (1) and C _ (3). The content of LDL-C and the activities of serum lipoprotein lipase (LPL) and liver lipase (HLL) were analyzed by SPSS17.0 software. 3 experimental results. Compared with the control group, the LDL-C levels in the blood of the drug group were significantly lower than those in the control group. However, HDL-C increased significantly (P < 0. 05), but there was no significant difference in serum TC and HDL-C during exercise for 40 minutes or 60 minutes. TG in the exercise group treated with 40min and 60min decreased significantly (P < 0. 01), and it was significantly lower than that in the control group (P < 0. 05 and P < 0. 05), and was significantly lower than that in the 40 min exercise group (P < 0. 05 and P < 0. 05), while that in the 40min and 60min exercise groups was significantly lower than that in the 40 min exercise group (P < 0. 05 and P < 0. 05). LDL-C in blood decreased significantly (P < 0. 05), while LDL-C in 40min exercise group was significantly lower than that in 40min exercise group (P < 0. 05), and was significantly lower than that in 40min exercise group (P < 0. 05), and was significantly lower than that in 40min exercise group (P < 0. 05). The activity of LPL in the serum of the treatment group and the 40min exercise group was significantly higher than that of the control group (P < 0. 05). The serum LPL activity in the 40min exercise group was significantly higher than that in the 40min exercise group (P < 0. 01), and was significantly higher than that in the control group (P < 0. 05), and was significantly higher than that in the control group (P < 0. 05). There was no significant effect on HL activity in both groups and other groups. 4 conclusion. 4.1 taking Jinkui Shenqi Pill alone can significantly inhibit the increase of TCU TGN LDL-C in blood of aged rats, and promote the increase of HDL-C content and LPL activity, suggesting that Jinguishenqi Pill can regulate lipid metabolism to some extent. 4.2 exercise could significantly reduce the content of serum TG-LDL-C and increase the activity of LPL in the blood of middle-aged and aged rats, suggesting that the appropriate exercise could improve the disorder of lipid metabolism in middle-aged and aged rats. 4.3 the combination of Jingui Shenqi pills and exercise has a significant effect on reducing the level of serum TGG LDL-C and increasing the activity of LPL in aged rats, and the effect is better than that of taking medicine and exercise alone. It suggested that Jingui Shenqi Pill combined with exercise had a good effect on regulating lipid metabolism in aged rats.
【学位授予单位】:曲阜师范大学
【学位级别】:硕士
【学位授予年份】:2012
【分类号】:G804.2

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