有氧运动对胰岛素抵抗形成过程中大鼠睾酮分泌的影响

发布时间：2018-04-13 22:05

本文选题：有氧运动 + 高脂膳食　；参考：《中国运动医学杂志》2015年12期

【摘要】：目的:探讨有氧运动对高脂膳食所致胰岛素抵抗形成过程中大鼠睾酮分泌的影响及相关机理。方法:雄性SD大鼠随机分为普通膳食组(C组,10只)、高脂膳食组(HF组,12只)、高脂膳食+运动组(HE组,13只),运动方案为60 min/次/天、每周6天、共10周的无负重游泳运动。10周后称取大鼠体重、肾周脂重和睾周脂重,测定血清空腹血糖(FBG)、甘油三酯(TG)、胆固醇(TC)、游离脂肪酸(FFA)、空腹胰岛素(FINS)、w酮(T)、卵泡刺激素(FSH)、促黄体生成素(LH)和瘦素(LP)水平,分析HOMA-IR、ISI。结果:(1)HF组大鼠肾周脂重、睾周脂重、FFA、LP较C组显著增加,FBG、TG、TC、FINS和HOMA-IR非常显著升高,T、FSH、LH、ISI显著下降。(2)与HF组比,HE组大鼠睾周脂重、肾周脂重、血清TG、TC、FFA、FBG、FINS与HOMA-IR非常显著下降,LP显著下降,FSH、LH、ISI显著上升,T非常显著上升。(3)HOMA-IR与FFA、FINS、LP显著正相关,与ISI显著负相关;T与LP、FINS、HOMA-IR显著负相关,与ISI显著正相关;LP与FINS显著正相关。结论:高脂膳食可以诱导大鼠形成胰岛素抵抗,导致睾酮分泌下降。有氧运动可改善高脂饮食诱导的糖脂代谢异常,提高胰岛素的敏感性,调节睾酮分泌。
[Abstract]:Aim: to investigate the effect of aerobic exercise on testosterone secretion during insulin resistance induced by high fat diet in rats.Methods: male SD rats were randomly divided into normal diet group (n = 10), high fat diet group (n = 12), high fat diet group (n = 13) and HE group (n = 13).A total of 10 weeks of weightless swimming exercise. 10 weeks later, the rats were weighed, including the weight of perirenal fat and the pericorchidism.The serum levels of FBGG, TG, TC, FFAF, FINS, FSHH, LHH and LPN were measured and the HOMA-IRISI was analyzed.Results compared with the HF group, the perinatal fat weight and the periddymal fat weight of the FFALP group were significantly higher than those of the C group. Results compared with that of the HF group, the periddymal fat weight and the renal perinatal fat weight of the HF group were significantly higher than that of the control group. The levels of TGG and HOMA-IR in the HF group were significantly higher than those in the HF group and that in the HF group, which were significantly higher than those in the HE group and that in the HF group, which were significantly higher than those in the HE group.Serum TGG TCA FBA FBA fins and HOMA-IR were significantly decreased and LP significantly decreased. FSHLHISI rose significantly. HHIS-IR was significantly positively correlated with FFAA FINSMA-LP, significantly negatively correlated with ISI, significantly negatively correlated with LPF-FINSHOMA-IR, and positively correlated with ISI. LHISI was significantly positively correlated with FINS.Conclusion: high fat diet can induce insulin resistance and decrease testosterone secretion in rats.Aerobic exercise can improve glucose and lipid metabolism induced by high fat diet, increase insulin sensitivity and regulate testosterone secretion.
【作者单位】：扬州大学体育学院;南京市觅秀街中学;
【基金】：江苏省教育厅重点实验室开放课题(K13034)
【分类号】：R87

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