实验兔肾动脉使用医用胶栓塞的可行性研究

发布时间：2018-04-14 11:23

本文选题：动物实验 + 肾动脉　；参考：《重庆医学》2015年35期

【摘要】：目的通过动物实验观察医用胶栓塞实验兔肾动脉的可行性及安全性,探讨不同栓塞剂浓度对血管栓塞过程及效果的影响,为其临床应用提供指导。方法用不同比例的超液化碘油与医用胶组成的混悬液对18只实验兔肾动脉进行栓塞,观察栓塞情况及效果。结果栓塞剂经导管注射顺利,可经微导管行反复栓塞,安全有效,栓塞可靠,均未见血管再通和造影剂外溢。术后病理检查HE染色后光学显微镜下见动脉内栓塞剂呈不规则形或分支状折光性透亮物质,其中,5∶1、4∶1组以细、小动脉栓塞为主,二者比较差异无统计学意义(P0.05),3∶1组以中型动脉栓塞为主,与5∶1组、4∶1组比较差异有统计学意义(P0.05),肾组织可见充血、变性、凝固性坏死、钙化及纤维组织增生等不同改变。术后肾功能呈一过性损害,白细胞一过性升高,1周后均恢复至术前水平,术后肝功能未见明显异常。结论医用胶栓塞实验兔肾动脉可行,不同浓度的医用胶可以选择性栓塞肾动脉各级分支。
[Abstract]:Objective to observe the feasibility and safety of medical glue embolization of renal artery in rabbits, and to explore the influence of different concentrations of embolic agent on the process and effect of embolization in order to provide guidance for its clinical application.Methods the renal arteries of 18 rabbits were embolized with different proportion of superliquefied lipiodol and medical glue.Results the embolization agent was successfully injected through the catheter and could be repeatedly embolized through microcatheter. The embolization was safe and effective, and the embolization was reliable. There was no recanalization of blood vessel and no contrast agent overflow.After HE staining, the intraarterial embolization agent showed irregular or branched refractive light transparent substance under optical microscope, in which 5: 1 + 4: 1 group was fine, and arteriole embolization was the main one.There was no significant difference between the two groups (P 0.05) and moderate arterial embolization was dominant in group 3: 1, and there was significant difference compared with group 4: 1 at 5:1 (P 0.05). Congestion, degeneration and coagulation necrosis were observed in renal tissue.Calcification and fibrous tissue proliferation were different.After operation, renal function showed transient damage, leukocyte increased temporarily and recovered to preoperative level 1 week later. Liver function was not abnormal after operation.Conclusion it is feasible to embolize the renal artery of rabbits with medical glue, and different concentrations of medical glue can selectively embolize all branches of renal artery.
【作者单位】：贵阳医学院附属医院放射科;
【基金】：贵州省科技计划课题基金资助项目(黔科合SY字[2012]3145号)
【分类号】：R816.7

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