蛋白组学相关技术在运动对骨骼肌重塑研究中的进展

发布时间：2018-04-15 12:33

本文选题：运动 + 骨骼肌　；参考：《中国运动医学杂志》2017年05期

【摘要】：运动对身体最直接的作用为重塑骨骼肌,但其潜在的分子机制仍不清楚。蛋白组学技术可为特定刺激物调节分子通路提供一个整体的视角,目前已在运动对骨骼肌重塑的作用机制方面取得一定进展。本文通过广泛查阅近些年来有关运动对骨骼肌重塑的蛋白组学研究报道,并进行总结分析。结果发现,可通过蛋白质分离技术结合蛋白质鉴定技术有效地检测出运动前后或运动组与安静对照组骨骼肌差异表达的蛋白质。通过运动可引起骨骼肌的适应性应答,蛋白质组会发生相应的调整。不同运动的类型、强度和持续时间以及肌纤维类型可引起骨骼肌蛋白质组的不同变化。随着现有技术的不断完善和更多新技术的产生,蛋白组学研究会为阐明运动对骨骼肌重塑及其改善健康的机制研究等做出更大的贡献。
[Abstract]:The most direct effect of exercise on the body is the remodeling of skeletal muscle, but its underlying molecular mechanism remains unclear.Proteomics can provide a holistic perspective for specific stimulators to regulate molecular pathways, and progress has been made in the mechanism of exercise on skeletal muscle remodeling.In this paper, we reviewed and analyzed the proteomics of skeletal muscle remodeling by exercise in recent years.The results showed that the protein differentially expressed in skeletal muscle before and after exercise or exercise group and quiet control group could be effectively detected by protein separation technique and protein identification technique.Exercise can induce adaptive response of skeletal muscle, proteome will be adjusted accordingly.Different types of exercise, intensity and duration, and muscle fiber types can cause different changes in skeletal muscle proteome.With the continuous improvement of existing technology and the production of more new technologies, proteomics research will make more contributions to clarify the mechanism of exercise on skeletal muscle remodeling and health improvement.
【作者单位】：复旦大学附属华山医院运动医学与关节镜外科;
【分类号】：R87

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