PET-CT最大标准摄取值定量评估胃癌组织中HER2的表达情况

发布时间：2018-04-19 16:09

本文选题：计算机断层扫描 + 正电子发射型计算机断层显像　；参考：《世界华人消化杂志》2016年15期

【摘要】：目的:探讨人表皮生长因子受体2(human epidermal growth factor receptor 2,HER2)表达程度与正电子发射断层扫描(positron emission tomography,PET)-CT标化摄取值(standardized uptake value,SUV)max的关系,从而定量评价胃癌组织中HER2表达情况,进而间接评价胃癌的生物学特性.方法:回顾性分析57例郑州大学第一附属医院胃腺癌患者的PET-CT扫描资料,测量最大标准摄取值.应用免疫组织化学方法检测胃癌中HER2的表达,用统计学方法分析SUVmax与HER2的相关性.结果:所有患者HER2阳性者28例,HER2表达阳性率为49.12%,按照统计学方法分析得出HER2阳性组SUVmax高于阴性组,且差异具有统计学意义(8.9357±4.21375 vs 4.6448±3.18597,P=0.000).SUVmax与HER2呈中度正相关,相关系数为0.581.以SUVmax为参考值绘制受试者工作特征曲线,曲线下面积为0.83,根据不同SUVmax值所对应特异度、灵敏度及约登指数可得出,当SUVmax值为5.800时所对应的约登指数越大,灵敏度为82.1%,特异度为79.8%.结论:胃癌组织中SUVmax与胃癌病灶中的H E R2的表达具有一定的相关性,能较好的评估胃癌的生物学特性.
[Abstract]:Objective: to investigate the relationship between the expression of human epidermal growth factor receptor 2(human epidermal growth factor receptor 2 (HER2) and positron emission tomographygraphy (PET) in order to evaluate the expression of HER2 in gastric carcinoma tissues.The biological characteristics of gastric cancer were evaluated indirectly.Methods: the PET-CT scan data of 57 patients with gastric adenocarcinoma in the first affiliated Hospital of Zhengzhou University were analyzed retrospectively and the maximum standard uptake was measured.Immunohistochemical method was used to detect the expression of HER2 in gastric cancer, and the correlation between SUVmax and HER2 was analyzed statistically.Results: the positive rate of hER2 expression was 49.12 in 28 patients with HER2 positive. According to the statistical analysis, the SUVmax in the HER2 positive group was higher than that in the negative group, and the difference was statistically significant (8.9357 卤4.21375 vs 4.6448 卤3.185970.000.SUVmax, the correlation coefficient was 0.581).The area under the curve was 0.83using SUVmax as the reference value. According to the specificity, sensitivity and Johden index of different SUVmax values, the higher the Yorden index was when the SUVmax value was 5.800, the sensitivity was 82.1 and the specificity was 79.8%.Conclusion: there is a certain correlation between the expression of SUVmax and the expression of H E R2 in gastric cancer, which can be used to evaluate the biological characteristics of gastric cancer.
【作者单位】：郑州大学第一附属医院放射科;郑州大学第一附属医院核医学科;
【基金】：国家自然科学基金项目,No.81271573~~
【分类号】：R735.2;R730.44

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