全身振动对去卵巢大鼠三种组织ER-α基因表达的影响

发布时间：2018-04-28 09:53

本文选题：全身振动 + 去卵巢大鼠　；参考：《中国运动医学杂志》2015年11期

【摘要】：目的:探讨全身振动治疗绝经后肥胖与骨质疏松的作用机理。方法:对体重相近的去卵巢3月龄雌性SD大鼠进行全身垂直振动训练,7周后测定受试大鼠血清雌激素、孕酮、睾酮、骨密度、体重以及肝、脂肪、骨骼肌组织中雌激素受体(ER)-α基因表达水平。结果:去卵巢振动训练组体重增加显著低于去卵巢静止组;去卵巢振动训练组股骨远端和近端的离体骨密度显著高于去卵巢静止组;去卵巢振动训练组大鼠肝脏、脂肪、骨骼肌组织中ER-α基因表达水平较去卵巢静止组显著增加;但去卵巢振动训练组与去卵巢静止组血清雌激素、孕酮、睾酮水平均较假手术组显著降低。结论:促进大鼠ER-α基因的表达是全身振动训练改善因性激素缺乏造成骨密度下降、体重增加等症状的机理之一。
[Abstract]:Objective: to explore the mechanism of systemic vibration in the treatment of postmenopausal obesity and osteoporosis. Methods: the serum estrogen, progesterone, testosterone, bone mineral density, body weight, liver and fat of ovariectomized female Sprague-Dawley rats with similar body weight were measured after 7 weeks of whole body vertical vibration training. Expression of estrogen receptor ERF- 伪 in skeletal muscle. Results: the weight gain of ovariectomized vibration training group was significantly lower than that of ovariectomized static group, the bone mineral density of distal femur and proximal end of ovariectomized vibration training group was significantly higher than that of ovariectomized static group, the liver, fat and fat of ovariectomized vibration training group, The expression of ER- 伪 gene in skeletal muscle tissue was significantly higher than that in ovariectomized static group, but the serum estrogen, progesterone and testosterone levels in ovariectomized and ovariectomized quiescent group were significantly lower than those in sham operation group. Conclusion: promoting the expression of ER- 伪 gene in rats is one of the mechanisms of systemic vibration training to improve the symptoms of bone mineral density loss and weight gain caused by sex hormone deficiency.
【作者单位】：西北农林科技大学;首都体育学院;
【基金】：国家自然科学基金项目(30771046)
【分类号】：R87

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