阿尔茨海默病及轻度认知损伤患者PET与MRI分析

发布时间：2018-05-01 09:24

本文选题：阿尔茨海默病 + 认知功能障碍　；参考：《中国医学影像技术》2017年11期

【摘要】：目的探讨PET葡萄糖代谢成像与MR结构成像诊断阿尔茨海默病(AD)与轻度认知损伤(MCI)的临床价值。方法收集AD患者18例(AD组)、MCI患者6例(MCI组),其中AD患者包括11例中重度AD(中重度AD组)及7例轻度AD(轻度AD组),另招募10名健康志愿者(对照组),同期进行PET与MR结构成像,通过视觉评价与定量分析法观察脑内放射性分布及海马萎缩情况。结果所有AD患者(18/18,100%)均可见脑内特定区域葡萄糖代谢减低,其中11例中重度AD患者均同时伴有海马萎缩,7例轻度AD患者中3例可见海马萎缩;MCI患者中,5例(5/6,83.33%)未见海马萎缩,但其中2例可见葡萄糖代谢减低。对照组(10/10,100%)均未见海马萎缩,其中2例可见轻度脑萎缩,FDG分布对称性轻度减低。结论 PET及MRI均可用于诊断AD与MCI,但各有侧重,二者联合应用有利于进一步提高对AD的诊断能力。
[Abstract]:Objective to evaluate the clinical value of PET glucose metabolism imaging and Mr structural imaging in the diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI). Methods A total of 18 patients with AD and 6 patients with MCI were enrolled. The AD patients included 11 moderate and severe AD patients and 7 mild AD patients. Another 10 healthy volunteers (control group) were recruited to perform PET and Mr structural imaging at the same time. Brain radioactivity distribution and hippocampal atrophy were observed by visual evaluation and quantitative analysis. Results decreased glucose metabolism in specific regions of the brain was found in all AD patients (18 / 18100). Among them, 11 patients with moderate and severe AD were accompanied by hippocampal atrophy. Of the 7 mild AD patients, 3 showed hippocampal atrophy in 5 out of 7 MCI patients with hippocampal atrophy (5 / 6 / 83.33) and no hippocampal atrophy was found in 11 patients with moderate and severe AD. But two of them showed decreased glucose metabolism. No hippocampal atrophy was found in the control group (10 / 10100), 2 of which showed mild cerebral atrophy and slight reduction in the symmetry of FDG distribution. Conclusion both PET and MRI can be used in the diagnosis of AD and MCI.
【作者单位】：西安交通大学第一附属医院医学影像科;西安交通大学第一附属医院临床研究中心;
【基金】：西安交通大学第一附属医院临床研究面上项目(XJTU1AF-CRF-2015-013)
【分类号】：R445.2;R749.16;R817.4

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