左侧乳腺癌保乳术后调强放疗有无均整器模式剂量学研究

发布时间：2018-05-07 13:55

本文选题：乳腺癌 + 放射治疗　；参考：《第三军医大学学报》2015年20期

【摘要】：目的比较6MV-X射线非均整模式(flattening filter-free,FFF)和均整模式(with flattening filter,WFF)在早期左侧乳腺癌保乳术后大分割调强放疗计划(intensity-modulated radiation therapy,IMRT)中的剂量学差异。方法选取10例左侧乳腺癌保乳术后放疗患者,分别设计FFF-IMRT和WFF-IMRT计划。在满足临床要求的情况下,比较2组计划的靶区和危及器官剂量体积直方图(DVH)、靶区适形度(CI)和均匀性(HI)、计划机器跳数(MU)和治疗时间。结果 FFF和WFF模式IMRT计划均能满足靶区剂量要求和危及器官剂量限值。两者靶区剂量分布相似,CI和HI无统计学差异。与WFF-IMRT相比,FFF-IMRT提高皮肤剂量(P0.001),降低靶区外正常组织、健侧乳腺与患侧肺的受量(P0.05),增加25%MU(P0.001),减少50%单次治疗时间(P0.001)。结论 2组计划均能满足临床治疗需求,FFF-IMRT计划更利于保护危及器官和缩短治疗时间。
[Abstract]:Objective to compare the dosimetric differences between 6MV-X ray nonuniform mode (6MV-X) and uniform mode with flattening filter (WFF) in intensity-modulated radiation therapeutic therapy (IMRT) after breast conserving surgery on the left side of breast cancer. Methods FFF-IMRT and WFF-IMRT were designed in 10 patients with left breast cancer after breast conserving surgery. Under the condition of meeting the clinical requirements, the target area and organ dose volume histogram (DVH) of the two groups were compared with that of the homogeneity (HI), the planned machine hopping (MUU) and the treatment time. Results both FFF and WFF model IMRT program could meet the target dose requirement and organ dose limit. There was no significant difference in dose distribution between the two groups. Compared with WFF-IMRT, FFF-IMRT increased the skin dose (P0.001), decreased the normal tissue outside the target area, increased the dose of 25% MUF-IMRT in the normal breast and the affected lung, and reduced the time of single treatment by 50% (P0.001). Conclusion FFF-IMRT can meet the need of clinical treatment.
【作者单位】：汕头大学医学院附属肿瘤医院放疗科;
【基金】：广东省医学科研基金(A2014455)
【分类号】：R730.55;R737.9

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