有氧运动对大鼠心肌细胞增殖的控制及调控机制的研究

发布时间：2018-05-09 02:20

本文选题：有氧运动 + SD大鼠　；参考：《黑龙江畜牧兽医》2017年07期

【摘要】：为了探讨有氧运动对SD大鼠心肌细胞增殖的影响,试验选取雄性SD大鼠30只,年龄控制在3月龄左右,体重在180~220 g,将其随机平均分为观察组(给予8周有氧运动)和对照组(笼内生活),对两组SD大鼠心肌细胞增殖情况进行对比观察。结果表明:两组SD大鼠体重差异极显著(P0.01);观察组与对照组相比,心率(HR)、舒张末压(LVEDP)呈显著降低趋势(P0.05);观察组与对照组相比,心脏重量、心系数、左室收缩压(LVSP)、左室压力上升以及下降速率的最大值(分别用+dp/dt max、-dp/dt max表示)显著升高(P0.05)。有氧运动对大鼠心脏功能具有非常显著的改善作用,并且大鼠心肌细胞存在一定的增殖现象,有氧运动使得促细胞凋亡因子得到一定程度的抑制,进而使心肌细胞凋亡现象受到抑制。说明有氧运动有利于诱发心肌细胞增殖因子,促进心肌细胞增殖。
[Abstract]:In order to investigate the effect of aerobic exercise on cardiomyocyte proliferation in SD rats, 30 male SD rats were selected and their age was controlled at about 3 months old. The rats were randomly divided into two groups: the observation group (8 weeks of aerobic exercise) and the control group (living in cage). The proliferation of cardiomyocytes in the two groups was compared. The results showed that the difference of body weight between the two groups was very significant (P0.01A), the heart rate (HRV) and end-diastolic pressure (LVEDPP) were significantly decreased in the observation group compared with the control group, and the heart weight and heart coefficient in the observation group were significantly lower than those in the control group. Left ventricular systolic pressure (LVSP), the maximum of left ventricular pressure rise and decrease rate (expressed by dp/dt max-dp / DT max, respectively) increased significantly (P 0.05). Aerobic exercise can significantly improve the cardiac function of rats, and there is a certain proliferation phenomenon in cardiomyocytes of rats. Aerobic exercise can inhibit apoptosis promoting factors to a certain extent. In turn, the phenomenon of cardiomyocyte apoptosis was inhibited. Aerobic exercise can induce cardiomyocyte proliferation factor and promote cardiomyocyte proliferation.
【作者单位】：郑州大学体育学院;
【基金】：河南省科技厅基础前沿项目“骨骼肌信号通路在运动后变化规律及对蛋白质合成调控研究”(14236513562)
【分类号】：R87

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