实验性胫骨骨折愈合过程中的X线表现与骨密度、骨灰重及钙磷元素、病理学变化的相关性分析

发布时间：2018-05-13 19:43

本文选题：胫骨骨折 + 骨折愈合　；参考：《中国临床医学影像杂志》2015年10期

【摘要】：目的:观察实验性胫骨骨折愈合过程中,X线表现与骨密度、骨灰重及钙磷元素含量及病理变化的相关性,从而确定骨折愈合不同时期X线表现对于判定骨折愈合情况及指导临床康复治疗的意义。方法:取(250±10)g左右的大鼠60只,随机分为2组,实验组采用锯开法造成胫骨骨折模型,对照组不做任何处理。在术后2周和4周两个时间点进行采样,测试大鼠胫骨的骨密度、骨灰重,拍摄X线片以及病理切片观察,检测术后2周的钙磷含量。结果:2周时,实验组的骨密度、骨灰重均与正常组有显著性差异,钙磷元素在两组之间具有显著性差异。X线片显示实验组表现出骨折线模糊,病变端密度增高,少量骨痂形成,病理学切片显示实验组均有新生骨小梁形成。4周时,两组之间的骨密度、骨灰重均没有显著性差异,X线片显示实验组的骨痂明显,病理学切片显示骨小梁粗大,并逐步融合成板状骨。结论:骨折愈合过程中,X线表现与骨密度、骨灰重、钙磷元素、病理变化呈正相关,可以判定骨折愈合情况,并指导临床康复治疗。
[Abstract]:Objective: to observe the correlation between X-ray findings and bone mineral density (BMD), bone ash weight, calcium and phosphorus content and pathological changes during experimental tibial fracture healing. So it is important to determine the X-ray manifestations in different stages of fracture healing for judging fracture healing and guiding clinical rehabilitation treatment. Methods: 60 rats (250 卤10 g) were randomly divided into 2 groups. The experimental group used sawing method to make tibial fracture model, while the control group did not do any treatment. Bone mineral density (BMD), bone ash weight (BMD) and bone ash weight (BMD) were measured at 2 and 4 weeks after operation. Results the bone mineral density (BMD) and bone ash weight (BMD) of the experimental group were significantly different from those of the normal group at 2 weeks. The X-ray film showed that the fracture line was blurred, the lesion end density was increased and a small amount of callus was formed in the experimental group. Histopathological sections showed that there was no significant difference in bone mineral density (BMD) and bone ash weight between the two groups when the trabeculae of the experimental group were formed at the 4th week, but the histopathological sections showed that the trabeculae of the experimental group were thicker than those of the control group. And gradually fused into a platelike bone. Conclusion: the X-ray findings of fracture healing are positively correlated with bone mineral density, bone ash weight, calcium and phosphorus, and pathological changes, which can be used to judge fracture healing and guide clinical rehabilitation therapy.
【作者单位】：中国中医科学院望京医院;
【基金】：国家自然科学基金面上项目(批准号:81373801)
【分类号】：R683;R816.8

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