运动对2,3,7,8-四氯二苯并二恶英急性暴露大鼠血清两种转氨酶活性及总胆固醇含量的影响

发布时间：2018-05-16 02:07

本文选题：-四氯二苯并二恶英 + 运动　；参考：《中国运动医学杂志》2017年06期

【摘要】：目的:探讨有氧运动对2,3,7,8-四氯二苯并二恶英(TCDD)急性暴露大鼠血清丙氨酸氨基转移酶(ALT)和天冬氨酸氨基转移酶(AST)活性及总胆固醇(TC)含量的影响。方法:40只雄性成年Wistar大鼠随机分为正常对照组(NC组)、单纯染毒组(NT组)、运动对照组(EC组)和运动染毒组(ET组)。染毒组(NT和ET组)一次性腹腔注射10μg/kg体重的TCDD(溶于玉米油),非染毒组(NC和EC组)一次性腹腔注射等量的玉米油;不运动组(NC和NT组)静养,运动组(EC和ET组)游泳(尾部负重5%,30 min/d,6d/周)。4周后测定血清ALT和AST活性及TC含量。结果:TCDD染毒明显提高血清AST活性,对ALT活性无明显影响,有氧运动对TCDD染毒引起的血清转氨酶活性变化无明显影响;TCDD染毒使血清TC水平明显升高,有氧运动能明显降低TCDD染毒引起的TC水平升高。结论:急性TCDD染毒后4周可致大鼠肝细胞损伤并引起胆固醇代谢异常;4周有氧运动对TCDD引起的肝细胞保护作用不明显,但可有效改善TCDD引起的高胆固醇血症。
[Abstract]:Objective: to investigate the effects of aerobic exercise on serum alanine aminotransferase (alt), aspartate aminotransferase (AST) activity and total cholesterol (TC) content in rats exposed to TCDD. Methods 40 male adult Wistar rats were randomly divided into normal control group (NC group), control group (NT group), exercise control group (EC group) and exercise exposure group (et group). TCDD (dissolved in corn oil, NC and EC groups) was injected intraperitoneally with 10 渭 g/kg body weight at a single time, and the same amount of corn oil was injected intraperitoneally in the control group (NC group and NT group). Exercise group (EC and et group) swimming (tail load 5 min / d ~ (6) d / week) after 4 weeks to determine the activities of serum ALT and AST and TC content. Results the activity of serum AST was significantly increased by the exposure of TCDD, but the activity of ALT was not affected by aerobic exercise, but the activity of serum transaminase induced by TCDD was not affected by aerobic exercise, and the level of serum TC was significantly increased by exposure to TCDD. Aerobic exercise could significantly reduce the increase of TC level caused by TCDD exposure. Conclusion: 4 weeks after acute TCDD exposure, hepatocyte injury and abnormal cholesterol metabolism can be induced in rats. Aerobic exercise for 4 weeks has no obvious protective effect on hepatic cells induced by TCDD, but it can effectively improve hypercholesterolemia induced by TCDD.
【作者单位】：浙江大学公共体育与艺术部;北京体育大学运动医学与康复学院;中国人民武装警察部队后勤学院;
【基金】：中央高校基本科研业务费专项资金资助课题(2016RB016) 全国重点地区环境与健康专项调查(21111011101EHH-2011-505)
【分类号】：R87

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