Echotracking联合microCT评价可降解支架植入后动脉弹性改变

发布时间：2018-06-06 01:16

本文选题：可降解支架 + Echotracking　；参考：《中国医学计算机成像杂志》2017年02期

【摘要】：目的:通过建立可降解支架植入兔腹主动脉模型,探讨echotracking联合mircoCT在支架降解过程中动态观察动脉弹性改变的价值。方法:24只新西兰大白兔于DSA下在其腹主动脉随机植入一枚可降解镁合金支架(JDBM组,n=12)或镍钛合金支架(BMS组,n=12),分别于术前和植入术后即时、14天、30天、60天行echotracking获得支架处血管硬化参数β,并在术后第14天、30天、60天取材行micro CT评价支架降解情况。结果:(1)观察期间支架无移位或断裂,支架内血流通畅。(2)Micro CT提示BMS支架无明显变化,JDBM支架术后30天起已开始降解,观察期间支架基本保持原始结构,合金丝连续性完整。(3)术前及术后即时、第14天两组间β值无明显统计学差异(P0.05),随植入时间的增加,JDBM组β值逐渐减小,BMS组β值逐渐增大;术后30天时JDBM组明显小于BMS组(P=0.036);术后60天时BMS组β值因支架处管壁无明显搏动无法获得。结论:Echotracking技术联合mirco CT可用于评价可降解镁合金支架植入后降解过程中血管弹性的改变情况。
[Abstract]:Aim: to investigate the value of echotracking combined with mircoCT in observing the changes of arterial elasticity in the process of stent degradation by establishing a rabbit model of degradable stent implantation. Methods Twenty four New Zealand white rabbits were randomly implanted with a degradable magnesium alloy stent JDBM group under DSA or nickel-titanium alloy stents group. The stents were obtained by echotracking 14 days before and 30 days after implantation and 60 days after implantation. The vascular sclerosis parameter 尾 was obtained on the 14th day, 30 days and 60 days after operation. The degradation of stent was evaluated by micro CT. Results (1) during the observation period, there was no displacement or rupture of the stent. Ct showed that there was no obvious change in the flow of blood flow in the stent. The stent began to degrade 30 days after operation, and the original structure of the stent was maintained during the observation period. Before and after operation, there was no significant difference in 尾 value between the two groups on the 14th day (P 0.05). The 尾 value of JDBM group gradually decreased with the increase of implantation time, and the 尾 value of BMS group gradually increased. On the 30th day after operation, the 尾 value of the JDBM group was significantly smaller than that of the BMS group, and the 尾 value of the BMS group could not be obtained because there was no obvious pulsation in the wall of the stent on the 60th day after the operation. Conclusion\% chotracking technique combined with mirco CT can be used to evaluate the changes of vascular elasticity during degradable magnesium alloy stent implantation.
【作者单位】：复旦大学附属华山医院;上海交通大学材料科学与工程学院;复旦大学附属浦东医院;
【分类号】：R54;R816.2

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