军事应激对新兵免疫功能的影响

发布时间：2018-06-07 23:22

本文选题：体液免疫 + 细胞免疫　；参考：《检验医学》2016年03期

【摘要】：目的探讨新兵军事训练前后机体细胞免疫和体液免疫的变化情况。方法从某部新兵集训基地选择参加入伍军事训练的新兵60名,分别在军事训练前和军事训练后进行症状自评量表(SCL-90)问卷调查,血清免疫球蛋白和补体功能的检测,NK细胞、B淋巴细胞、CD4+T淋巴细胞、CD8+T淋巴细胞及白细胞介素2(IL-2)、白细胞介素10(IL-10)含量的检测。结果新兵军事训练后SCL-90总分及躯体化、抑郁、偏执因子分值较军事训练前显著升高(P0.05);军事训练后血清Ig G、Ig A和Ig M水平,B淋巴细胞和NK细胞数量,外周血CD4+T淋巴细胞数、CD8+T淋巴细胞数和CD4+/CD8+比值较军事训练前均明显降低(P0.05或P0.01);军事训练后外周血IL-2水平较军事训练前明显降低(P0.05),IL-10水平较军事训练前明显升高(P0.05),辅助性T淋巴细胞(Th)1/Th2比值军事训练后明显低于军事训练前(P0.05)。结论由军事训练引起的军事应激可引起新兵免疫功能的降低。
[Abstract]:Objective to investigate the changes of cellular and humoral immunity in recruits before and after military training. Methods A total of 60 recruits enrolled in military training were selected from a new recruit training base and were investigated with symptom Checklist 90 (SCL-90) before and after military training. Detection of serum immunoglobulin and complement function the contents of CD 4 T lymphocytes, CD 8 T lymphocytes, interleukin 2 (IL 2) and interleukin 10 (IL 10) in B lymphocytes of NK cells were determined. Results the total score of SCL-90, somatization, depression and paranoid ideation in recruits after military training were significantly higher than those before military training (P 0.05), and the numbers of B lymphocytes and NK cells in serum Ig A and IgG M were increased after military training. The number of peripheral blood CD4 T lymphocytes and the ratio of CD4 / CD8 were significantly lower than those before military training (P0.05 or P0.01), and the level of IL-2 in peripheral blood after military training was significantly lower than that before military training, and the level of IL-10 in peripheral blood was significantly higher than that before military training. After military training, the ratio of Th1 / Th2 of helper T lymphocytes was significantly lower than that of P0.05 before military training. Conclusion military stress caused by military training can decrease the immune function of recruits.
【作者单位】：白求恩国际和平医院;
【基金】：河北省自然科学基金青年基金(H2014505009)
【分类号】：R82

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