跟腱腱病的易感基因研究进展

发布时间：2018-06-22 16:48

  本文选题：跟腱 + 腱病　； 参考：《中国运动医学杂志》2017年11期

【摘要】：跟腱腱病是跟腱的过度使用性损伤,其具体发病机制和病因尚不清楚。目前认为是一个多因素导致的疾病,分为内因和外因。其中,基因因素是重要的内因之一,也是目前研究的热点。已发现白细胞介素1(IL-1)、肿瘤坏死因子α(TNF-α)、细胞素-金属基质蛋白酶(MMPs)、胶原蛋白基因COL5A1等基因与跟腱腱病有关。明确跟腱腱病与易感基因的具体机制有利于该疾病的治疗和预后。
[Abstract]:Achilles tendon disease is an overuse injury of Achilles tendon. The pathogenesis and etiology of Achilles tendon are unclear. The disease is now considered to be a multifactorial disease, divided into internal and external causes. Among them, gene factor is one of the important internal factors, and it is also the hot spot of current research. Interleukin-1 (IL-1), tumor necrosis factor- 伪 (TNF- 伪), cytokine metalloproteinases (MMPs) and collagen gene COL5A1 have been found to be associated with Achilles tendon disease. Understanding the specific mechanism of Achilles tendon disease and susceptibility gene is beneficial to the treatment and prognosis of the disease.
【作者单位】： 复旦大学附属华山医院运动医学科;
【分类号】：R873
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本文编号：2053484