一种模拟运动后颈总动脉振荡切应力的流动腔装置

发布时间：2018-06-27 18:33

本文选题：振荡切应力 + 流动腔　；参考：《水动力学研究与进展A辑》2015年06期

【摘要】：为离体研究运动对颈总动脉内皮细胞功能的影响,该文设计并构建了模拟运动后颈总动脉振荡切应力的流动腔装置。通过建立五元件集中参数模型,以33名男性健康大学生急性有氧运动后颈总动脉处的振荡切应力特征值和波形图为模拟目标,利用Matlab Simulink软件包进行数值仿真确定输入流量率和各元件参数值,选择合适的元件进行装置的搭建以及调试。结果表明,该文设计和构建的装置能产生稳定的振荡切应力波形,且能较好模拟急性有氧运动后颈总动脉处的振荡切应力特征值及波形图。该文装置将为离体研究运动后振荡切应力影响内皮细胞的分子生物学机制提供较理想的实验平台。
[Abstract]:In order to study the effect of exercise on the function of endothelial cells in common carotid artery in vitro, a flow chamber was designed and constructed to simulate the oscillatory shear stress of common carotid artery after exercise. By establishing a five-element concentrated parameter model, the oscillatory shear stress characteristic value and waveform of common carotid artery of 33 male healthy college students after acute aerobic exercise were used as the simulation target. By using Matlab Simulink software package, the input flow rate and the parameters of each component are determined by numerical simulation, and the appropriate components are selected to build and debug the device. The results show that the apparatus designed and constructed in this paper can produce stable oscillatory shear stress waveform and can simulate the characteristic value and waveform of oscillatory shear stress in the common carotid artery after acute aerobic exercise. This device will provide an ideal experimental platform for studying the molecular biological mechanism of oscillatory shear stress on endothelial cells after exercise in vitro.
【作者单位】：大连理工大学工业装备结构分析国家重点实验室工程力学系;大连理工大学电信学部生物医学工程系;大连医科大学附属第一医院麻醉科;
【基金】：国家自然科学基金(11172060;31370948) 辽宁省自然科学基金(2015020303) 中央高校基本科研业务费(DUT15QY12)~~
【分类号】：R87

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