心外膜脂肪密度与冠状动脉斑块的相关研究

发布时间：2018-06-29 04:31

本文选题：冠状动脉疾病 + 心包　；参考：《中国临床医学影像杂志》2015年03期

【摘要】：目的:探讨CT测量心外膜脂肪组织的密度与冠状动脉粥样硬化斑块的关系。方法:417例疑似冠心病患者行多螺旋CT造影检查,精确测量相应心外膜脂肪密度。根据造影检查结果分为斑块组及非斑块组,并进一步将斑块组分为3个亚组,即钙化斑块组、混合斑块组、非钙化斑块组,并按照不同性别和年龄分组,比较斑块侧与非斑块侧心外膜脂肪密度。结果:1417例患者纳入研究,其中斑块组189例,其中钙化斑块者42例,非钙化斑块59例,混合斑块83例;无斑块者228例。2斑块侧心外膜脂肪密度(以CT值比较)高于非斑块侧,两者之间存在统计学差异(40.84±37.28 vs.23.81±30.81,P=0.000),无论男性还是女性,斑块侧心外膜脂肪密度均高于非斑块侧(男,t=8.78,P=0.000;女,t=5.941,P=0.000);按年龄分层后,心外膜脂肪密度在45岁组以下(t=7.012,P=0.000)、45~55岁组(t=3.459,P=0.002)、55~65岁组(t=5.416,P=0.000)、65岁以上组(t=7.750,P=0.000)均为斑块组大于非斑块组,均存在统计学意义;斑块侧与非斑块侧心外膜脂肪密度均以非钙化斑块组的值最高,钙化斑块组最低,差异有统计学意义。相同性质各斑块组内斑块侧心外膜脂肪密度均大于非斑块侧,差异有统计学意义。结论:心外膜脂肪密度与冠状动脉粥样硬化斑块形成存在密切关系,与斑块性质有关。
[Abstract]:Objective: to investigate the relationship between density of epicardial adipose tissue and coronary atherosclerotic plaque measured by CT. Methods multihelical CT angiography was performed in 417 patients with suspected coronary heart disease and the epicardial fat density was measured accurately. The plaque group was further divided into three subgroups: calcified plaque group, mixed plaque group, non-calcified plaque group, and divided into three groups according to sex and age. The epicardial fat density of plaque side and non plaque side was compared. Results one hundred and seventeen patients were included in the study, including 189 cases in plaque group, 42 cases in calcified plaque, 59 cases in non-calcified plaque, 83 cases in mixed plaque, 228 cases without plaque, 228 cases with plaque side, the epicardial fat density (compared with CT value) was higher than that in non-plaque side. There was a statistical difference between the two groups (40.84 卤37.28 vs.23.81 卤30.81P0.000). The epicardial fat density of plaque side was higher in male and female than that in non-plaque side (male = 8.78 P0.000; female = 5.941 P = 0.000); after age stratification, the density of epicardial fat in plaque side was higher than that in non-plaque side. The density of epicardial fat under 45 years old group (tn 7.012 P0. 000) and 45 + 55 years old group (tng 3. 459 P0. 002) 55 years old group (t 5. 416 P0. 000) and above 65 years old group (t0. 750 P0. 000) were all higher than that of non-plaque group, and there was statistical significance in both plaque side and non-plaque epicardial membrane fat density in non-calcified plaque group, the highest in non-calcified plaque group, and there was no significant difference between non-calcified plaque group and non-calcified plaque group in both plaque side and non-plaque group Calcified plaque group was the lowest, the difference was statistically significant. The epicardial fat density of the plaque side in the same plaque group was higher than that in the non-plaque side, and the difference was statistically significant. Conclusion: epicardial fat density is closely related to the formation of coronary atherosclerotic plaque and related to the nature of plaque.
【作者单位】：河北联合大学附属开滦总医院影像科;
【分类号】：R541.4;R816.2

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