KGN修复软骨、促进腱-骨愈合作用的研究进展

发布时间：2018-07-10 16:45

本文选题：Kartogenin + 腱-骨愈合　；参考：《山东医药》2017年16期

【摘要】：交叉韧带断裂、肩袖损伤等肌腱损伤是常见的运动损伤,腱-骨连接结构愈合是其治疗关键,但其愈合困难是目前临床一大难题。促进腱-骨愈合是修复肌腱损伤、防止再撕裂的关键,但是目前还没有能有效、持续促进肌腱损伤修复术后腱-骨连接结构恢复的方法。应用各种来源的干细胞及细胞因子等生物治疗方法在促进腱-骨愈合方面受到了广泛关注,其中骨髓间充质干细胞(BMSCs)是研究的热点。小分子化合物Kartogenin(KGN)被发现能够显著诱导BMSCs向软骨分化,具有极强的促进软骨形成和腱-骨愈合作用,且与药物释放系统整合后能更好的发挥效能。本文就KGN修复软骨、促进腱-骨愈合方面的研究作一综述,为临床上促进软骨修复、提高腱-骨损伤的治疗效果提供新思路。
[Abstract]:Tendon injuries such as cruciate ligament rupture and rotator cuff injury are common sports injuries. The healing of tendon-bone junction structure is the key to its treatment, but the difficulty of healing is a major clinical problem at present. Promoting tendon-bone healing is the key to repair tendon injury and prevent further tear, but there is no effective method to promote the recovery of tendon-bone junction structure after tendon injury repair. The application of stem cells and cytokines has attracted much attention in the field of tendon-bone healing, among which bone marrow mesenchymal stem cells (BMSCs) are the focus of research. Kartogenin (KGN), a small molecule compound, has been found to induce the differentiation of BMSCs into cartilage, which can promote cartilage formation and tendon-bone healing, and can play a better role when integrated with drug release system. This article reviews the research on the repair of cartilage and the healing of tendon-bone by KGN, which provides a new idea for promoting cartilage repair and improving the therapeutic effect of tendon-bone injury in clinic.
【作者单位】：解放军昆明总医院;
【基金】：国家自然科学基金资助项目(81360274) 云南省应用基础研究项目(2014FZ106)
【分类号】：R873

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