促性腺激素释放激素类似物对化疗患者卵巢功能保护有效性的系统分析

发布时间：2018-07-10 12:20

本文选题：“促性腺激素释放激素类似物／促性腺激素释放激素激动剂/促性腺激素释放激素抑制剂” + “化学治疗／化疗”　；参考：《福建医科大学》2013年硕士论文

【摘要】：目的评价促性腺激素释放激素类似物预防化疗所致卵巢功能损害的临床效果。方法采用电子数据库PubMed、西文生物医学期刊文献数据库(FMJS）、中文期刊全文数据库(CNKI)、万方数字知识服务平台、维普中文科技期刊数据库，检索词包括“促性腺激素释放激素类似物／促性腺激素释放激素激动剂/促性腺激素释放激素抑制剂”，“化学治疗／化疗”，“卵巢功能”；“GnRHa”，“chemotherapy”，“ovarian damage／ovarian function／premature ovarian failure”，搜索试验组化疗前使用促性腺激素释放激素类似物(戈舍瑞林、曲普瑞林、抑那通)，对照组化疗前未使用促性腺激素释放激素类似物的随机对照试验和临床对照试验。提取的数据采用RevMan5.1.7软件进行Meta分析。结果纳入文献7篇共624例，其中各研究具有较好的同质性(I2=0%，P0．05)，，可以进行合并分析，采用固定效应模型分析，结果显示促性腺激素释放激素类似物能有效预防化疗所致卵巢功能损害(P0．01)。受纳入文献数量和质量的限制，本次Meta分析结果尚有待于高质量的大样本随机对照试验予以证实。
[Abstract]:Objective to evaluate the clinical effect of gonadotropin releasing hormone analogue in preventing ovarian dysfunction induced by chemotherapy. Methods PubMed, FMJS, CNKI, Wanfang digital knowledge service platform, Weipu Chinese science and technology journal database were used. Keywords include "gonadotropin releasing hormone analogue / gonadotropin releasing hormone agonist / gonadotropin releasing hormone inhibitor", "chemotherapy / chemotherapy", "ovarian function", "GnRHa", "chemotherapy", "ovarian damage/ovarian function/premature ovarian failure", search trial group before chemotherapy using gonadotropin releasing hormone analogue (Goserelin, trapraline, The control group did not use gonadotropin releasing hormone analogue before chemotherapy in a randomized controlled trial and a clinical controlled trial. The extracted data were analyzed by Meta with Revman 5.1.7 software. Results A total of 624 cases were included in 7 articles. Among them, each study had good homogeneity (I2P 0.05), which could be analyzed by combination analysis and fixed effect model analysis. The results showed that gonadotropin releasing hormone analogue could effectively prevent ovarian dysfunction induced by chemotherapy (P0.01). Limited by the quantity and quality of the literature, the results of this meta-analysis have yet to be confirmed by a large sample of high quality randomized controlled trials.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R818.05

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