基于CTVision图像引导肺癌放疗过程中的肿瘤体积变化及位移研究

发布时间：2018-07-25 18:08

【摘要】：目的:基于西门子CTVision图像引导肺癌自适应放疗过程,分析患者肿瘤体积及位移变化情况。方法:采集11例肺癌患者放疗CT图像,与计划CT图像进行图像配准,比较放疗前与放疗中期肿瘤体积退缩情况以及在左、右、腹、背、头和脚这6个方向上的位置变化。结果:经自适应放疗,放疗中期11位患者肿瘤体积均有缩小,平均退缩率为43.2%,平均每天的退缩率为1.1%。患者肿瘤完全退缩为0例,微小退缩为4例,稳定退缩的肿瘤病灶为7例。大体肿瘤在左、脚、背侧位移最大,放疗前与放疗中期在6个方向上的位移有统计学意义(P0.05)。结论:肺癌放疗过程中,靶区体积会发生一定程度的退缩,且位移改变较明显,应在放疗过程中根据靶区体积和位置的变化情况,对放疗计划进行必要的调整。
[Abstract]:Objective: to analyze the changes of tumor volume and displacement in patients with lung cancer guided by Siemens CTVision images. Methods: the CT images of 11 patients with lung cancer were collected and registered with the planned CT images. The volume withdrawal of the tumor before and during radiotherapy and the changes of the position in the left, right, abdomen, back, head and foot were compared. Results: after adaptive radiotherapy, the tumor volume of 11 patients was reduced, the average withdrawal rate was 43.2%, and the average daily withdrawal rate was 1.1%. There were 0 cases of complete retraction, 4 cases of minimal withdrawal and 7 cases of stable retraction. The displacement of gross tumor in left, foot and dorsal was the largest, and the displacement in 6 directions before radiotherapy and in the middle of radiotherapy was statistically significant (P0.05). Conclusion: during radiotherapy of lung cancer, the volume of target area will shrink to a certain extent, and the displacement will change obviously. The radiotherapy plan should be adjusted according to the change of volume and position of the target area during radiotherapy.
【作者单位】：广州医科大学附属肿瘤医院放疗中心;
【基金】：国家自然科学基金(81170078) 广东省教育厅特色创新项目(2014KTSCX104) 广州市医药卫生科技项目(20161A011084)
【分类号】：R734.2;R730.55

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