经皮穴位电刺激对大运动量耐力训练大鼠骨骼肌形态学影响

发布时间：2018-09-13 15:38

【摘要】：目的:观察经皮穴位电刺激(TEAS)对大运动量耐力训练大鼠骨骼肌超微结构的影响。方法:将40只雄性SD大鼠随机分为正常组、模型组、正常刺激组、治疗组1、治疗组2,每组8只。模型组和治疗组的大鼠进行8周大运动量跑台训练,治疗组1于跑台训练前1 h进行TEAS干预,治疗组2于跑台训练后1 h进行相同TEAS干预;正常刺激组不进行跑台训练,干预方法同治疗组;正常组不进行运动训练及TEAS干预。8周跑台训练结束后,取同一部位的腓肠肌肌腹观察超微结构。结果:与正常组相比,正常刺激组骨骼肌超微结构无明显变化,而模型组大鼠骨骼肌Z线增粗扭曲,明暗带模糊,肌原纤维排列紊乱,部分断裂,局部肌丝甚至消失,横纹不规则,肌节长短不一,线粒体肿胀,大小不一;治疗组1和治疗组2与模型组相比,骨骼肌超微结构损伤较小。结论:TEAS可以减轻大鼠因大运动量耐力训练导致的骨骼肌损伤,具有一定防治运动性骨骼肌疲劳的作用。
[Abstract]:Aim: to observe the effect of (TEAS) on the ultrastructure of skeletal muscle in rats with large exercise endurance training. Methods: forty male SD rats were randomly divided into normal group, model group, normal stimulation group, treatment group 1, treatment group 2, each group with 8 rats. The rats in the model group and the treatment group were trained for 8 weeks, the rats in the treatment group 1 received TEAS intervention 1 hour before the treadmill training, the treatment group 2 did the same TEAS intervention at 1 h after the treadmill training, and the normal stimulation group did not carry out the treadmill training. The intervention method was the same as the treatment group, the normal group did not carry on the exercise training and the TEAS intervention 8 weeks after the end of the treadmill training, the gastrocnemius muscle of the same site was taken to observe the ultrastructure. Results: compared with the normal group, the ultrastructure of skeletal muscle in the normal stimulation group had no obvious change, while in the model group, the Z line of skeletal muscle was thickened and distorted, the light and dark zone was blurred, the myofibrils were arranged in disorder, some of the myofilms were broken, and the local myofilament even disappeared. Compared with the model group, the ultrastructural damage of skeletal muscle in treatment group 1 and treatment group 2 was less than that in model group. ConclusionTEAS can reduce the skeletal muscle injury caused by endurance training in rats, and it can prevent and treat the fatigue of skeletal muscle induced by exercise.
【作者单位】：福建中医药大学针灸学院;上海中医药大学针灸推拿学院;
【基金】：国家自然科学基金资助项目(81403453) 福建省卫生厅青年科研项目(2012-1-29) 上海高校选拔优秀青年教师科研专项基金(SZY10007) 上海市卫生局中医药科研基金项目(2012QL016A)
【分类号】：R87

【相似文献】