甘肃地区回族人群18个STR基因座的遗传多态性

发布时间：2018-10-21 13:11

【摘要】：研究了D5S818、D8S1179、D7S820、CSF1PO、D2S1338、D3S1358、v WA、D21S11、D16S539、Penta E、TPOX、TH01、D19S433、D18S51、FGA、D6S1043、D13S317、D12S391等18个短串联重复序列(short tandem repeats,STR)基因座在甘肃地区回族人群的遗传多态性。采用荧光标记复合扩增及毛细管电泳技术对1 038名甘肃地区回族无关个体18个STR基因座进行分析。研究结果显示,1 038名甘肃地区回族个体在18个STR基因座上,共检出223种等位基因,982种基因型,其分布均符合Hardy-Weinberg平衡(P0.05),18个基因座的杂合度(H)介于0.601~0.929之间,匹配概率(Pm)介于0.012~0.213之间,个体识别概率(DP)介于0.787~0.988之间,多态信息含量(PIC)介于0.550~0.920之间,非父排除概率(PE)值介于0.292~0.854之间。本文研究结果对甘肃地区回族人群群体遗传学及法医学后续研究应用具有参考价值。
[Abstract]:The genetic polymorphisms of D5S818 D8S1179 (D7S820) CSF1POF1POF1POD2S1338 (D3S1358) v WA,D21S11,D16S539,Penta TPOX TH01D19S433D18S51FGAA D6S1043D13S317D12S391) were studied. The 18 STR loci of 1038 Hui unrelated individuals in Gansu were analyzed by fluorescence labeling multiplex amplification and capillary electrophoresis. The results showed that a total of 223 alleles and 982 genotypes were detected at 18 STR loci in 1038 Hui individuals in Gansu province. The distribution of these alleles was consistent with Hardy-Weinberg balance (P0.05). The heterozygosity (H) of 18 loci was between 0.601 and 0.929, and the matching probability (Pm) was between 0.012 and 0.213. The individual identification probability (DP) was between 0.787 ~ 0.988, the polymorphic information content (PIC) was between 0.550 and 0.920, and the non-paternal exclusion probability (PE) was between 0.292 and 0.854. The results of this study are valuable for further study on population genetics and forensic medicine of Hui population in Gansu area.
【作者单位】：公安部物证鉴定中心;
【基金】：中央级公益性科研院所基本科研业务费专项资金项目(2015JB016);中央级公益性科研院所基本科研业务费专项资金项目(2015JB023);中央级公益性科研院所基本科研业务费发展支撑项目(2016JB040)
【分类号】：D919

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