PET-CT图像融合在生物靶区定义中的应用

发布时间：2018-10-21 13:31

【摘要】：目的:本研究探讨PET-CT图像融合对生物靶区(BTV)定义的影响。方法:采集行PET-CT图像融合患者3例。放疗前均行18F-FDG PET-CT检查,均在VARIAN治疗计划系统融合成PET-CT图像。由4名有经验的放疗医师分别基于单纯CT和融合图像在第1天和第8天定义GTVCT和GTVPET-CT,比较组内和组间差异;数据处理采用SPSS17.0统计软件,检验水准α=0.05。结果:PET-CT图像融合前后不同时间分别定义GTV,多数医师单纯CT下定义GTVCT差异有统计学意义(P0.05)。多组比较方差分析结果显示,单纯CT下勾画GTVCT差异有统计学意义(F=66.529,P=0.000;F=18.762,P=0.000;F=6.681,P=0.000)。两两比较LSD-t检验结果显示,不同医师定义GTVCT多组间差异有统计学意义(P0.05)。图像融合后4位医师勾画GTVPET-CT比单纯CT下勾画GTVCT的变异系数(CV)减小。结论:PET-CT图像融合可以提高靶区勾画的准确性,减小观察者间和观察者本身的变异。
[Abstract]:Objective: to investigate the effect of PET-CT image fusion on the definition of biological target (BTV). Methods: three patients with PET-CT image fusion were collected. 18F-FDG PET-CT was performed before radiotherapy and PET-CT images were fused into VARIAN treatment planning system. The differences between GTVCT and GTVPET-CT, were defined by four experienced radiotherapy physicians on day 1 and day 8 based on simple CT and fusion images, respectively. The data were processed by SPSS17.0 statistical software and the test level was 伪 = 0.05. Results: before and after PET-CT image fusion, there were significant differences in the definition of GTVCT between most doctors of GTV, and CT (P0.05). The results of ANOVA showed that there was a significant difference in GTVCT with CT alone (F = 66.529, P = 0.000, F = 18.762, P = 0.000, F = 6.681, P = 0.000). The results of LSD-t test showed that there were significant differences in the definition of GTVCT between different doctors (P0.05). After image fusion, the coefficient of variation (CV) of GTVCT sketched by four physicians was lower than that of CT alone. Conclusion: PET-CT image fusion can improve the accuracy of target delineation and reduce the variation between observers and observers themselves.
【作者单位】：郑州大学第一附属医院放射治疗部;
【分类号】：R730.55

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