心电图早复极作为运动性心血管风险预判指标的可行性研究

发布时间：2019-01-28 21:22

【摘要】：研究目的:通过对无运动习惯而心电图存在早复极现象的男性大学生进行急性力竭运动干预,根据心电图及心血管风险相关生化指标变化,探讨用心电图早复极预判运动性心血管风险的可行性。研究方法:以北京体育大学学科专业20名男性受试者为研究对象,其中11名受试者安静时心电图有早复极现象(ER),其余9名心电图正常(Non-ER)。通过经典Bruce运动方案提供急性力竭刺激,同时记录心率、血压、心电图变化。运动前、运动后6小时和24小时分别抽取静脉血5ml,检测心肌损伤炎症因子cTnI、cTnT、CK-MB、hs-CRP的变化。采用描述型统计方法归纳心电图变化,通过重复测量和独立样本T检验方法分析心肌损伤标志物的组内、组间差异。研究结果:ER组大多数受试者在运动中和运动后J点抬高和ST段上斜型抬高现象消失,但有1名受试者QRS波终末处切迹和顿挫明显存在,2名受试者心肌损伤炎症因子cTnT及hs-CRP一过性升高。而Non-ER组血压、心电图和心肌损伤炎症因子无异常变化。研究结论:鉴于ER组部分受试者在运动中心电图及心肌损伤炎症因子有异常变化,而Non-ER组未发现异常变化,提示早复极作为预判运动性心血管风险的可能性,但需进一步加大样本加以证实。
[Abstract]:Objective: to study the effects of acute exhaustive exercise on male college students with no exercise habit and early repolarization in electrocardiogram (ECG), according to the changes of electrocardiogram (ECG) and cardiovascular risk related biochemical indexes. To explore the feasibility of early repolarization electrocardiogram (ECG) in predicting the risk of exercise cardiovascular disease. Methods: a total of 20 male subjects majoring in subjects of Beijing University of physical Education were studied. Among them, 11 subjects had early repolarization phenomenon in their electrocardiogram (ER),) while they were quiet. The rest 9 subjects had normal electrocardiogram (Non-ER). Acute exhaustion stimulation was provided through classic Bruce exercise regimen, and heart rate, blood pressure and electrocardiogram were recorded. Before exercise, 6 hours and 24 hours after exercise, venous blood was taken from 5 ml to detect the change of inflammatory factor cTnI,cTnT,CK-MB,hs-CRP. The changes of electrocardiogram (ECG) were induced by descriptive statistical method. The differences of myocardial injury markers were analyzed by repeated measurement and independent sample T test. The results showed that most of the subjects in the ER group disappeared during and after exercise, but in one of the subjects, the notch and cadence at the end of the QRS wave obviously existed, and the oblique elevation of the ST segment disappeared during and after the exercise. Myocardial injury inflammatory factors cTnT and hs-CRP were temporarily elevated in 2 subjects. In Non-ER group, there were no abnormal changes in blood pressure, electrocardiogram and inflammatory factors of myocardial injury. Conclusion: in view of abnormal changes in electrocardiogram and inflammatory factors of myocardial injury in some subjects of ER group, but no abnormal changes were found in Non-ER group, it was suggested that early repolarization could be used to predict the risk of exercise-induced cardiovascular disease. But more samples are needed to confirm it.
【学位授予单位】：北京体育大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R87

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