CTA评价冠状动脉管壁可扩张度与冠心病主要危险因素的关系
发布时间：2019-05-12 12:37
【摘要】：目的 探讨冠状动脉管壁可扩张度与冠心病主要危险因素的关系。 材料和方法 入组118例受试者，包括43例健康老年人（其中男性14名，平均年龄56±4岁），25例高血压患者（其中男性12名，平均年龄60±6岁），31例高脂血症患者（其中男性18名，平均年龄60±6岁），19例糖尿病患者（其中男性9名，平均年龄59±6岁），对全部受试者测量血压并进行冠状动脉CTA扫描，分别测量收缩末期和舒张中期左前降支近端距左主干开口以远7mm处管腔横截面积，可扩张度（CDI）=［（收缩末期管腔面积－舒张中期管腔面积）／〔脉压差×舒张末期管腔面积〕］×1000，，脉压差计为肱动脉收缩压与舒张压的差，比较各组病人冠状动脉管壁可扩张度的差异。 结果 高血压、高脂血症、糖尿病病人冠状动脉可扩张度均比对照组健康人群减小。健康人冠状动脉可扩张度为5.24±1.40mmHg~(-1)×10~3，高血压、高脂血症、糖尿病患者冠状动脉可扩张度分别3.66±1.39mmHg~(-1)×10~3，3.72±1.39mmHg~(-1)×10~3，3.30±0.84mmHg~(-1)×10~3，高血压、高脂血症、糖尿病病人与健康人的冠状动脉扩张度有差异，P0.001。 结论 1.高血压、高脂血症、糖尿病的病人与健康人的冠状动脉管壁可扩张度均有显著差异。 2.高血压组、高脂血症组、糖尿病组病人之间冠状动脉可扩张度没有显著差异。高血压、高脂血症、糖尿病病人冠状动脉的可扩张度比正健康人群明显减低，冠状动脉可扩张度（CDI）明显受冠心病已知的主要危险因素的影响，CDI能可靠评估血管功能障碍的减低程度。
[Abstract]:Objective to investigate the relationship between dilatability of coronary artery wall and main risk factors of coronary heart disease (CHD). Materials and methods 118 subjects, including 43 healthy elderly (14 males, mean age 56 卤4 years) and 25 hypertensive patients (12 males, mean age 60 卤6 years), were enrolled in the study. Thirty-one patients with hyperlipidemia (18 males, mean age 60 卤6 years) and 19 patients with diabetes mellitus (9 males, mean age 59 卤6 years) were enrolled in this study. Blood pressure was measured and coronary artery CTA scan was performed in all subjects. The cross section area of the lumen near the proximal end of the left anterior descending branch from the left trunk opening to the far 7mm was measured at the end of contraction and the middle diastolic period, respectively. Dilatability (CDI) = [(end-systolic lumen area-mid-diastolic lumen area) / (pulse pressure difference 脳 end-diastolic lumen area) 脳 1000, pulse pressure difference is the difference between brachial artery systolic and diastolic pressure, The distensibility of coronary artery wall in each group was compared. Results the coronary artery distensibility in patients with hypertension, hyperlipidemia and diabetes mellitus was lower than that in the control group. The dilatation degree of coronary artery in healthy subjects was 5.24 卤1.40 mmHg~ (- 1) 脳 10 鈮
本文编号：2475398
[Abstract]:Objective to investigate the relationship between dilatability of coronary artery wall and main risk factors of coronary heart disease (CHD). Materials and methods 118 subjects, including 43 healthy elderly (14 males, mean age 56 卤4 years) and 25 hypertensive patients (12 males, mean age 60 卤6 years), were enrolled in the study. Thirty-one patients with hyperlipidemia (18 males, mean age 60 卤6 years) and 19 patients with diabetes mellitus (9 males, mean age 59 卤6 years) were enrolled in this study. Blood pressure was measured and coronary artery CTA scan was performed in all subjects. The cross section area of the lumen near the proximal end of the left anterior descending branch from the left trunk opening to the far 7mm was measured at the end of contraction and the middle diastolic period, respectively. Dilatability (CDI) = [(end-systolic lumen area-mid-diastolic lumen area) / (pulse pressure difference 脳 end-diastolic lumen area) 脳 1000, pulse pressure difference is the difference between brachial artery systolic and diastolic pressure, The distensibility of coronary artery wall in each group was compared. Results the coronary artery distensibility in patients with hypertension, hyperlipidemia and diabetes mellitus was lower than that in the control group. The dilatation degree of coronary artery in healthy subjects was 5.24 卤1.40 mmHg~ (- 1) 脳 10 鈮
本文编号：2475398
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