末端病与细胞外基质:骨腱结合部重要蛋白及酶类的关系尚需深入研究

发布时间：2019-05-31 19:52

【摘要】：背景:近年来,关于末端病的相关研究正逐渐成为运动医学和康复领域的研究热点,而细胞外基质在末端病的发生、发展和愈合过程中起着不可忽视的作用。目的:探讨末端病和细胞外基质间的关系。方法:检索中国期刊网全文数据库(中国知网CNKI)、维普数据库、中国生物医学文献数据库(CBM)、中国医药学位论文全文数据库(万方)及PubMed数据库和Embase医药数据库。从胶原、蛋白聚糖、糖蛋白以及基质重塑几方面入手,检索了2000年以来一些相关的研究成果并进行了综述。结果与结论:分析表明,末端病发生后,无论是胶原、蛋白聚糖、糖蛋白以及相关的酶类都发生明显的变化,这些指标的变化又影响着末端病的重建和修复过程。目前的研究大多集中在肌腱部分,关注骨腱结合部的研究相对较少,而且许多重要蛋白及酶类与末端病的关系、以及运动干预效果的研究仍不够深入。
[Abstract]:Background: in recent years, the research on terminal disease has gradually become a hot topic in the field of sports medicine and rehabilitation, and extracellular matrix plays an important role in the occurrence, development and healing of terminal disease. Objective: to investigate the relationship between terminal disease and extracellular matrix. Methods: the full-text database of Chinese Journal Network (China knowledge Network CNKI), Weipu Database, Chinese Biomedical Literature Database (CBM), Chinese Medical thesis full-text Database (Wanfang), PubMed Database and Embase Medical Database) were searched. From the aspects of collagen, proteoglycan, glycoprotein and matrix remodeling, some related research results since 2000 were searched and reviewed. Results & conclusion: after the occurrence of terminal disease, both collagen, proteoglycan, glycoprotein and related enzymes changed obviously, and the changes of these indexes affected the reconstruction and repair process of terminal disease. At present, most of the studies focus on the tendon, the research on the junction of bone tendon is relatively few, and the relationship between many important proteins and enzymes and terminal disease, as well as the effect of exercise intervention is still not deep enough.
【作者单位】：玉林师范学院体育学院;北京体育大学;
【基金】：广西高校人文社会科学研究项目(YB2014312) 2009玉林师范学院院级重点项目(2009YJZD15)~~
【分类号】：R87

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