微重力对细菌致病性的影响

发布时间：2018-01-05 07:22

本文关键词：微重力对细菌致病性的影响　出处：《解放军医学杂志》2013年01期 　论文类型：期刊论文

【摘要】：微重力是太空飞行中重要的环境影响因素之一。研究发现空间站和航天飞行器上可检出多种细菌。空间环境或模拟微重力会对大肠埃希菌、沙门菌、铜绿假单胞菌等条件致病菌产生影响,导致其在毒力、生物被膜和耐药性等方面发生改变。引发前述变化的机制尚不明确,但业已证明RNA结合蛋白Hfq的调控与空间环境或模拟微重力所致的多种基因变化有关,而空间环境或模拟微重力所致的细菌致病性增加可能会影响宇航员的健康。本文就微重力对细菌致病性的影响及其机制作一综述,以期为维护航天飞行中宇航员的健康和治疗感染性疾病提供思路。
[Abstract]:Microgravity is one of the important environmental impact of space flight factors. The study found that the space station and the spacecraft can be detected in many kinds of bacteria. The space environment and simulated microgravity can against Escherichia coli, Salmonella, Pseudomonas aeruginosa and other opportunistic pathogens affected, resulting in virulence, biological membrane and drug resistance was changed. The mechanism of causing changes is not clear, but it has been proved that the gene changes of RNA binding protein Hfq and regulation of space environment and simulated microgravity induced by pathogenic bacteria, and the space environment and simulated microgravity induced increase may influence the health of astronauts. The microgravity effects on bacterial pathogenicity and its mechanism review, in order to provide ideas for health maintenance and treatment of astronauts in space flight of infectious diseases.

【作者单位】：解放军总医院南楼呼吸科;
【基金】：武器预研重点基金(9140A26040312JB10078) 航天医学基础与应用国家重点实验室开放基金(SMFA11K02) 中国博士后科学基金第四批特别资助项目(201104776) 国家自然科学基金(81000018)~~
【分类号】：R852.22
【正文快照】： 随着人类对太空的涉足,有关空间生命科学的研究越来越深入。在人体表面、呼吸道和胃肠道均寄居着大量与人类健康息息相关的细菌。研究发现,在微重力条件下,一些条件致病菌的毒力和致病性增加[1],可对宇航员的健康产生威胁。目前,有关微重力环境下细菌致病性变化的研究越来越

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