飞行员高尿酸血症调查及危险因素分析

发布时间：2018-01-09 21:54

本文关键词：飞行员高尿酸血症调查及危险因素分析　出处：《解放军医学杂志》2012年01期 　论文类型：期刊论文

【摘要】：目的分析飞行员高尿酸血症的发病情况,研究高尿酸血症与其他心血管疾病危险因素的关系。方法以2005-2010年在空军总医院例行体检的2563名飞行员为研究对象,分为高尿酸(420μmol/L)组(n=294)和正常尿酸组(n=2269),比较其高血压、高血糖、高血脂发生率,并以飞行员血尿酸(UA)为因变量,胆固醇(CHO)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、空腹血糖(BG)、收缩压(SBP)、舒张压(DBP)、吸烟情况、体重等指标为自变量进行logistic多元回归分析,确定UA水平与这些指标的关系。结果与正常尿酸组相比,高尿酸组高血压、高CHO、高TG、低HDL、高LDL发生率明显增高(P0.01)。Logistic多元回归分析显示,高UA水平与TG(OR=1.637,P0.01)、DBP(OR=1.025,P0.01)、体重水平(OR=1.046,P0.01)关系密切。结论飞行员血清UA水平和其他心血管疾病的危险因子密切相关。
[Abstract]:Objective to analyze the incidence of hyperuricemia in pilots. To study the relationship between hyperuricemia and other cardiovascular risk factors. Methods 2563 pilots who underwent physical examination in Air Force General Hospital from 2005 to 2010 were studied. The patients were divided into hyperuricemia group (420 渭 mol / L) and normal uric acid group. The incidence of hypertension, hyperglycemia and hyperlipidemia were compared. The pilots' serum uric acid (UAA) was used as dependent variable, cholesterol, triglyceride, high density lipoprotein (HDL), low density lipoprotein (LDLN), fasting blood glucose (BGG). Systolic blood pressure (SBP), diastolic blood pressure (DBP), smoking status and body weight were analyzed by logistic regression analysis. Results compared with the normal uric acid group, the high uric acid group had hypertension, high Cho, high TG and low HDL. The incidence of high LDL was significantly increased (P 0.01). Logistic multiple regression analysis showed that the high UA level was significantly higher than that in the control group (P 0.01). The body weight of DBP was 1.025 and the body weight level was 1.046. Conclusion the level of serum UA in pilots is closely related to the risk factors of other cardiovascular diseases.
【作者单位】：空军总医院临床检验中心;
【分类号】：R589.7;R85
【正文快照】： 尿酸(UA)是嘌呤的代谢产物,其水平升高不仅可能诱发痛风,而且与脂质代谢紊乱、糖尿病、高血脂、肥胖等疾病密切相关[1]。心血管疾病是飞行员停飞的重要原因之一,也是造成飞行员死亡的重要因素[2]。本研究对例行体检的飞行员血清UA水平进行测定,并系统分析UA水平和多个心血管

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