唑吡坦预防急性高原反应随机双盲安慰剂对照研究

发布时间：2018-01-18 01:37

本文关键词：唑吡坦预防急性高原反应随机双盲安慰剂对照研究　出处：《解放军医学杂志》2015年09期 　论文类型：期刊论文

【摘要】：目的观察急性高原暴露后唑吡坦预防急性高原反应(AMS)的效果。方法采用高原现场随机双盲对照的研究方法,将40名受试者随机分为唑吡坦组与安慰剂组,分别在平原与高原采集一般资料、血压、心率、血氧饱和度、匹兹堡睡眠质量指数评分、AMS评分及体能测试结果。结果急性高原暴露后,唑吡坦组匹兹堡睡眠质量指数评分明显低于安慰剂组(P=0.047)。唑吡坦组6min步行距离明显大于安慰剂组(P=0.009)。不同时间点唑吡坦组AMS发病率均明显低于安慰剂组(P值分别为0.019、0.014、0.025、0.026),其中唑吡坦组各时间点的重度AMS发病率均低于安慰剂组(P值分别为0.047、0.044、0.031和0.020)。急性高原暴露20h后,唑吡坦组虚弱、疲劳、眩晕症状明显轻于安慰剂组(P0.05)。急性高原暴露后两组心率、血压、氧饱和度、体力活动能力、左右手握力无明显差异(P0.05)。结论唑吡坦能减轻AMS症状,降低AMS发病率,可望成为预防AMS的新选择。
[Abstract]:Objective to observe the effect of zolpidem on the prevention of acute altitude reaction (AMS) after acute high altitude exposure. Forty subjects were randomly divided into zolpidem group and placebo group. General data, blood pressure, heart rate, blood oxygen saturation, Pittsburgh sleep quality index were collected in plain and high altitude. AMS score and physical fitness test results after acute exposure to high altitude. The score of Pittsburgh sleep quality index in zolpidem group was significantly lower than that in placebo group (P 0.047), and the 6-minute walking distance in zolpidem group was significantly larger than that in placebo group (P 0.009). The incidence of AMS in zolpidem group at different time points was significantly lower than that in placebo group (P = 0.019). The incidence of severe AMS in zolpidem group was lower than that in placebo group (P = 0.047 卤0.044). The symptoms of weakness, fatigue and vertigo in Zolpidem group were significantly lighter than those in placebo group (P 0.05) after acute high altitude exposure for 20 h. The heart rate and blood pressure in the two groups after acute high altitude exposure were significantly lower than those in the control group (P < 0.05). There was no significant difference in oxygen saturation, physical activity and grip strength between left and right hand. Conclusion Zolpidem can alleviate the symptoms of AMS and reduce the incidence of AMS, and it is expected to be a new choice for the prevention of AMS.
【作者单位】：第三军医大学新桥医院心血管内科全军心血管病研究所;
【基金】：国家卫生部卫生行业科研专项基金(201002012)~~
【分类号】：R82
【正文快照】： 明,快速进入高原时,乙酰唑胺与阿司匹林和安慰剂相比,并未能显著降低AMS的发生率[1]。此外,地塞米松虽也能有效预防AMS,但不良反应较大,使其应用受到限制[2]。高原睡眠障碍既是AMS主要临床表现之一,也是影响AMS发生与发展的独立因素[3]。非苯二氮类药物唑吡坦半衰期短、安全性

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