坐位下体负压对人体生理心理功能影响的实验研究

发布时间：2018-02-27 11:42

本文关键词： 坐位下体负压大脑中动脉血流速度 G致意识丧失血氧饱和度事件相关电位反应时跟踪误差正确率心率血压　出处：《第四军医大学》2002年硕士论文　论文类型：学位论文

【摘要】： 飞行中飞行员可能暴露于+Gz环境下，+Gz负荷引起脑血流量减少到临界值时，所发生的意识突然丧失的状态称为G致意识丧失(G-LOC)。近年来，随着高性能战斗机的发展，高G值(＞9G)，快增长率(＞6G/s)的持续性正加速度的医学防护，特别是高过载致空中意识丧失的预防和监控，对降低G-LOC的发生率，预防飞行事故的发生，提高飞行部队的战斗力，仍是航空航天医学研究的重要课题之一。下体负压(LBNP)是模拟重力-惯性力场对人体循环功能影响的有效研究方法之一，在一定程度上可模拟正加速度对人体的影响。鉴于未来高技术战争的需要和飞行部队的实际，有必要探讨下体负压对人体脑血流和脑认知功能的影响，以此作为检测G-LOC的手段和方法。本实验的目的在于：1)观察坐位下体负压条件下人体大脑中动脉血流速度及耳部血氧饱和度的变化；2)探讨坐位下体负压对人体脑事件相关电第四草医大学硕士学位论文一位爬RPX 反应时（RTX跟踪误差oR）等大脑认知功能的影响，为空中晕厥和立位耐力不良的医学鉴定提供人体实验依据。本研究选取13叫名青年男性作为被试者。每名被试者均要在两种坐位下体负压条件下各进行两个实验。两种负压条件分别为：t．00 kPa（－30 InmHg）和－6．67 kPa（50 mlnHg卜每个实验要在每种负压条件下各测试 5 min，以负压前 5 min测试的指标作为对照。实验一，15名被试者，主要观察坐位下体负压条件下对人体大脑中动脉血流速度（V。c。L血氧饱和度（SaO＊和心率（HR）的影响。实验二，13名被试者，主要观察坐位下体负压条件下视觉 Oddball模式诱发的脑事件相关电位、双任务反应时、正确率aR郴跟踪误差的变化c 同时进行血压（BP）和心率的检测。两个实验均记录被试者的主观症状和客观体征。其上要实验结果如下： 1．坐位下体负压对人体大脑中动脉血流速度、心率和血氧饱和度的影响。在－4．00 kPa下体负压作用4、5 min时，脑血流速度减慢（尸＜0．05）；负压作用3、4、smln时。0率增快沪＜o5）；血氧饱和度无明显改变。在巧石7 Wa下体负压作用2、3 min时，脑血流速度减慢什＜几05）在4和5 min时显著减慢o＜0．of），卸压后 lmin尚未恢复，随后恢复至对照水平；负压作用后各时间点。乙率均显著增快沪叩刀1＼血氧饱和度在负k暴露5加D时明显下降（尸＜0刀5）。 2．坐位下体负压对脑认知工效及心血管功能的影响。在4刀0 kPa下体负压作用时，Psoo波幅（AMP）、Psoo潜时（LAT）、双任务反应时、跟踪误差、血压与负压前对照无明显差别：心率在下体负压作用3、4、5叫n 时，显著增快什＜0刀5卜在6石7wa下体负压作用时，马皿波幅显著降低（＜0．05），p300潜时显著延长（p＜0．05）；反应时延长（＜0．05），足踪误差增大沪刃仍）：心率在负压作用各时问点与负压作用前比较均显著增快什＜o01）；．二l－第四罕医大学硕士学位论文一收缩压与负压前对照无明显改变，舒张压显著升高（P＜0．05）。实验结果表明，坐位下体负压造成大脑中动脉血流速度减慢，引起大脑供血量减少，血液在下肢积聚，大脑对外界刺激的反应减慢，脑认知工效下降，同时心血管部分代偿功能加强，心率增快，，血压升高，为空中晕厥和立位耐力不良的医学鉴定提供了人体实验依据。
[Abstract]:The pilot in flight may be exposed to the +Gz environment, +Gz load caused by cerebral blood flow is reduced to a critical value, the sudden loss of consciousness state called G induced loss of consciousness (G-LOC). In recent years, with the development of high performance fighter, high G value (> 9G), fast growth rate (> 6G/s) medical protection sustained positive acceleration, especially high overload caused by the prevention and monitor of unconsciousness, to reduce the incidence of G-LOC, prevention of flight accidents, improve flight fighting force, is still an important subject of aerospace medicine.
Lower body negative pressure (LBNP) is one of the gravity and inertia force field effect on the human body circulatory function effective simulation method, which can simulate the effects of acceleration on the human body to a certain extent. In view of the actual needs of the future high-tech war and flying units, it is necessary to study the effect of lower body negative pressure on blood flow and cognitive function of human brain and as a means and method for detection of G-LOC.
The purpose of this experiment is: 1) to observe the changes of blood flow velocity and blood oxygen saturation of human middle cerebral artery under the condition of sitting lower body negative pressure; 2) to explore the relative electrical activity of the body under the seat negative pressure.
Fourth master's degree thesis
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The effects of the cognitive function of the brain, such as the RPX response (RTX tracking error oR), for syncope in the air and in the air.
The medical identification of the poor orthostatic tolerance provides the basis for the human experiment.
This study selected 13 young men called as subjects. All subjects were sitting in two
The two experimental conditions. A lower body negative pressure of two kinds of negative pressure conditions were: t.00 kPa (30
InmHg) and - 6.67 kPa (50 mlnHg divination experiments each test 5 under each negative pressure condition
Min, the index of the 5 min test before negative pressure was used as the control.
Experiment 1, 15 subjects, mainly observe the motion of the body's brain under the lower body negative pressure of the seat.
The effect of blood flow velocity (V.c.L oxygen saturation (SaO * and heart rate (HR)) on the blood flow velocity (HR).
Experiment two, 13 subjects, mainly observe the visual Oddball model under the negative pressure of the sitting position.
Type of brain evoked event-related potentials, dual task reaction time changes, the correct rate of aR Chenzhou tracking error C
At the same time, blood pressure (BP) and heart rate were tested.
The subjective symptoms and objective signs of the subjects were recorded in the two experiments. The results of the experiment were as follows:
The effect of 1. seat lower body negative pressure on the blood flow velocity, heart rate and oxygen saturation of the middle cerebral artery in the human body
Ring. In kPa 4,5 min 4.00 LBNP, cerebral blood flow velocity (P < 0.05); negative
The pressure of 3,4 and smln increase the.0 rate in Shanghai < O5 >; the blood oxygen saturation has no obvious change. In Qiao 7
When the lower body negative pressure of Wa is 2,3 min, the velocity of cerebral blood flow slows down more than 05) at 4 and 5 min
O < 0.of was significantly slowed down, and lmin was not restored after pressure relief, and then recovered to the control level; negative pressure was used.
After each time point. B were significantly increased at 1, Shanghai knife 5 plus D exposure to oxygen saturation in the negative K Ming
Declines (corpse < 0 knife 5).
The effect of lower body negative pressure on brain cognitive ergonomics and cardiovascular function in 2. sitting position under 4 knife and 0 kPa
When body negative pressure, Psoo amplitude (AMP), Psoo latent time (LAT), double task reaction, tracking
There is no significant difference between the blood pressure and the negative pressure before the negative pressure: the heart rate in the lower body negative pressure 3,4,5 is called n
At the time, the amplitude of the horse dish decreased significantly when the 0 knife and 5 divination was under the negative pressure of the 6 stone 7wa.
(< 0.05), the latent time of P300 was prolonged significantly (P < 0.05); the reaction time was prolonged (< 0.05) and the foot and trace error increased
The rate of heart rate in negative pressure was significantly higher than that before negative pressure.
Two L -
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There was no significant change in the systolic pressure and the control before the negative pressure, and the diastolic pressure increased significantly (P < 0.05).
The experimental results show that the lower body pressure of the sitting position causes the decrease of the velocity of the middle cerebral artery in the cerebral artery.
A decrease in the amount of brain blood supply, the accumulation of blood in the lower extremities, the slowing of the brain's response to external stimuli, and the cognitive work of the brain
At the same time, the compensatory function of the cardiovascular part is strengthened, the heart rate is faster, the blood pressure is raised, and the air halo is in the air.
The medical identification of bad syncope and erect stamina provides the basis for human experiment.

【学位授予单位】：第四军医大学
【学位级别】：硕士
【学位授予年份】：2002
【分类号】：R852

【引证文献】