舰船邻舱爆炸致比格犬脑损伤的实验研究

发布时间：2018-03-02 16:06

本文选题：邻接舱室　切入点：爆震伤　出处：《解放军医学杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的通过建立比格犬邻舱爆震伤实验模型,探讨该工况下颅脑爆震伤的病理生理变化,并推测可能的致伤机制。方法建造与实际舰船等大小的连续舱室,从7只比格犬中随机选取1只,颅内植入微型压力传感器,用于冲击波压力的测定,其余6只用于各项病理生理指标的检测。将犬固定于爆源邻舱的机柜平台上,以650g TNT当量的裸药爆炸致伤,用传感器记录空间与颅内冲击波压力值,并观察爆后犬血清IL-6、IL-8、神经元特异性烯醇化酶(NSE)的含量,头颅和胸部CT的影像学改变及脑组织病理学变化。结果试验犬血清IL-6、IL-8、NSE水平在爆后均有不同程度的升高,与爆前值比较差异有统计学意义(P0.05)。头颅和胸部CT检查未发现明显阳性结果。病理检测结果显示脑内可见少许坏死区,部分神经元出现核固缩深染,核溶解或核仁消失,细胞界限模糊。大部分冲击波(约90%)被头皮和颅骨阻挡,但仍有少部分可穿透而致伤脑组织。结论舰船邻舱爆炸主要引起轻型颅脑损伤,头皮与颅骨对冲击波具有较强的阻挡作用。
[Abstract]:Objective to study the pathophysiological changes of craniocerebral explosive injury and to speculate on the possible injury mechanism by establishing the experimental model of blast injury in the adjacent compartment of Beagle canine. Methods continuous cabin of the same size as the actual ship was constructed. One of 7 Beagle dogs was randomly selected and micropressure sensor was implanted into the skull to measure the shock wave pressure. The remaining 6 dogs were used to detect the pathophysiological indexes. The dogs were fixed on the cabinet platform of the adjacent compartment of the explosion source. 650g TNT equivalent naked drug explosion was used to record the space and the pressure of intracranial shock wave, and to observe the content of IL-6 IL-8 and neuron-specific enolase (NSE) in canine serum after explosion. Results the serum levels of IL-6 and IL-8 NSE in dogs were increased in different degrees after explosion. The difference was statistically significant (P 0.05) compared with the values before explosion. No positive results were found in CT examination of the head and chest. Pathological examination showed that there were some necrotic areas in the brain, some neurons had deep staining of nuclear pyknosis, nuclear dissolution or nucleolus disappearance. Most of the shock waves (about 90%) were blocked by scalp and skull, but a few of them could penetrate and injure brain tissue. Scalp and skull have strong blocking effect on shock wave.
【作者单位】：解放军医学院;海军总医院神经外科;
【基金】：国家自然科学基金(81372128) 全军后勤科研重大项目(AHJ14J001)~~
【分类号】：R82

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