猪腰段脊髓火器伤对肾脏及其功能的影响

发布时间：2018-03-04 20:01

本文选题：脊髓火器伤　切入点：肾脏　出处：《中国矫形外科杂志》2006年14期 　论文类型：期刊论文

【摘要】：[目的]建立猪腰段脊髓火器伤模型和改良A llen's打击伤后全瘫模型,观察伤后肾脏病理和肾功能的早期变化。[方法]动物随机分为两组,火器伤组(G)6只,在全麻状态下做L1~2脊髓火器伤模型;打击伤组(A)6只,L1节段脊髓行改良A llen's打击。两组动物分别于伤前(0 h)、伤后0.5 h、1 h、2 h、4 h检测血肌酐和血尿素氮(BUN)。死亡动物行肾脏病理检查。[结果]A组BUN值在伤后4 h升高,G组BUN值在伤后1 h升高。两组肌酐在伤后0.5 h升高,各点监测G组明显高于A组。G组动物伤后5.2 h~7.5 h死亡,死亡率为100%。病理检查示G组肾包膜及肾实质广泛充血、出血。[结论]G组火器伤较A组肾脏损伤及组织破坏严重,在伤后早期出现肾功能变化。脊髓火器伤后肾功能变化早期应给予积极处理,以降低早期死亡率。
[Abstract]:[objective] to establish the model of spinal cord firearm injury in pigs and to observe the early changes of renal pathology and renal function after injury with modified A llen's. [methods] the animals were randomly divided into two groups, 6 rats in firearm injury group. The model of spinal cord firearm injury was established under general anesthesia. Six rats in the hit group were treated with modified A llen's. The serum creatinine and blood urea nitrogen bun were detected at 0 h before injury and 0 h after injury, respectively. The renal pathological examination was performed in the dead animals. [results] the BUN value of group A was 4 hours after injury. The BUN of G group increased at 1 h after injury, and creatinine increased at 0. 5 h after injury in both groups. The death rate of group G was significantly higher than that of group A at 5.2 h and 7.5 h after injury, and the mortality was 100. Pathological examination showed that the renal capsule and renal parenchyma in group G were congested extensively and bleeding. [conclusion] the firearm injury in group G is more serious than that in group A. The changes of renal function after spinal cord firearm injury should be actively dealt with in order to reduce the early mortality.
【作者单位】：解放军第175医院骨科全军创伤骨科中心解放军第175医院骨科全军创伤骨科中心上海市长征医院骨科上海市长征医院骨科上海市长征医院骨科
【基金】：全军“十五”计划指令性课题基金(编号01L056)
【分类号】：R82

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