高频正弦波振动对失重性肌萎缩的对抗作用

发布时间：2018-03-07 14:32

本文选题：模拟失重　切入点：高频振动　出处：《西安交通大学学报(医学版)》2003年06期 　论文类型：期刊论文

【摘要】：目的　探讨高频正弦波振动对模拟失重条件下大鼠比目鱼肌萎缩的对抗作用。方法　将SD大鼠按体重匹配的原则随机分为同步对照 (CON)、模拟失重 (SUS)、模拟失重 +高频振动 (SUS +HFV) 3组。 7d后 ,取大鼠比目鱼肌(SOL)称其湿重 ,计算其湿重体重比。采用组织酶化学染色及计算机图象分析技术对大鼠比目鱼肌I、II型肌纤维比例、横截面积 (CSA)进行定量分析。结果　与CON组对比 ,SUS组比目鱼肌湿重体重比、横截面积明显减小 ,同时I型纤维比例减少而II型纤维比例增加 (P 0 .0 5 )。SUS +HFV组比目鱼肌湿重体重比、横截面积及I、II型纤维的构成比与CON组对比均无明显差异 (P 0 .0 5 )。结论　高频正弦波振动能有效地对抗模拟失重引起的大鼠比目鱼肌萎缩
[Abstract]:Objective to investigate the antiatrophy effect of high frequency sine wave vibration on soleus muscle atrophy in rats under simulated weightlessness. Methods SD rats were randomly divided into three groups according to the principle of body weight matching: conus, simulated weightlessness, and simulated weightlessness. High frequency vibration group (SUS HFV). 7 days later, The wet weight of soleus muscle was taken and the ratio of wet weight to weight was calculated. The proportion of Ig II muscle fibers in rat soleus muscle was determined by histoenzyme staining and computer image analysis. Results compared with CON group, the wet weight / body weight ratio of soleus muscle in Sus group decreased significantly. At the same time, the proportion of type I fibers decreased and the proportion of type II fibers increased. The wet weight / body weight ratio of soleus muscle was increased in the group of P0. 05 and Sus HFV. There was no significant difference in cross sectional area and the ratio of type II fibers between the CON group and the CON group. Conclusion High frequency sine wave vibration can effectively combat soleus muscle atrophy induced by simulated weightlessness in rats.
【作者单位】：西安交通大学医学院生理学教研室西安交通大学医学院生理学教研室西安交通大学医学院生理学教研室西安交通大学医学院生理学教研室
【基金】：国家自然科学基金项目 (No .30 0 70 830 )
【分类号】：R852

【共引文献】