对急性贫铀中毒的促排措施研究

发布时间：2018-03-12 23:30

本文选题：贫铀　切入点：促排　出处：《第三军医大学学报》2008年06期 　论文类型：期刊论文

【摘要】：目的比较常见的几种贫铀促排剂,寻找高效低毒的药物或组合方案。方法分别在给予贫铀溶液前1h、立即、延迟4h给予碳酸氢钠、Tiron、dimethylthiourea(DMTU)和diethylenetriaminepenta-methylene phosphonic acid(DTPMP)及相应的组合方案,并在3d后进行肾功能检测及病理学观察。结果提前给药,血清尿素氮和肌酐浓度下降程度显著(P0·05),下降最明显的是NaHCO3+DMTU组和单用DTPMP组;立即给药,尿素氮和肌酐显著降低的是NaHCO3+DM-TU组、单用NaHCO3组和单用Tiron组(P0·05);延后给药,肾功能均未见明显改善(P0·05)。提前给药和立即给药,NaHCO3+DMTU组肾脏病变最轻;延后给药,病变比提前给药和立即给药的严重,其中以单用Tiron组肾脏病变最轻。结论急性贫铀中毒时,提前1h和立即给药时,NaHCO+DMTU合用效果较好;延后4h给药,单用Tiron的效果相对较好。
[Abstract]:Objective to compare several kinds of DU promoters and to find out high efficiency and low toxicity drugs or combinations. Methods 1 hour before the administration of DU solution, 4 h delay in the administration of sodium bicarbonate dimethylthioureahyde (DMTU) and diethylenetriaminepenta-methylene phosphonic acidine DTPMP) and the corresponding combination scheme, respectively. After 3 days of administration, the serum urea nitrogen and creatinine concentration decreased significantly (P 0.05). The most significant decrease was in NaHCO3 DMTU group and DTPMP group. Urea nitrogen and creatinine were significantly decreased in NaHCO3 DM-TU group, NaHCO3 group and Tiron group, but no significant improvement of renal function was found in delayed administration group, and no significant improvement was found in renal function. Early administration and immediate administration of NaHCO3 DMTU group had the lightest renal lesion, delayed administration of Naco 3 DMTU group, and delayed administration of Naco 3 DMTU group, there was no significant improvement in renal function in the delayed administration group, but no significant improvement in renal function was found in the delayed administration group. The pathological changes were more serious than that of early administration and immediate administration, especially in Tiron group, the renal lesion was the lightest. Conclusion the combination of NaHCO DMTU and NaHCO DMTU is better in acute depleted uranium poisoning than that in Tiron group.
【作者单位】：第三军医大学军事预防医学院防原医学教研室
【基金】：国家自然科学基金(30500144) 全军医学科研“十一五”计划专项课题(06Z031)~~
【分类号】：R82

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