聚丙烯补片与脱细胞真皮基质补片及传统方法修复战伤性腹壁软组织缺损的比较

发布时间：2018-03-16 09:52

本文选题：脱细胞真皮基质　切入点：聚丙烯　出处：《中国组织工程研究与临床康复》2009年29期 　论文类型：期刊论文

【摘要】：背景:近年来随着各种新型的人工合成修补材料问世,应用这类材料修补疾病所致的腹壁缺损也取得了很好的效果,但应用于战伤腹壁缺损的研究较少。目的:比较脱细胞真皮基质、聚丙烯补片以及传统方法修补战伤腹壁缺损的有效性和安全性。设计、时间及地点:随机对照动物实验,于2008-01/08在解放军第四军医大学西京医院及唐都医院动物实验外科实验室完成。材料:脱细胞真皮基质由烟台正海生物技术有限公司提供;聚丙烯补片购于北京。方法:27只成年杂种犬制作腹部开放伤动物模型后,随机分为3组,分别以脱细胞真皮基质、聚丙烯补片、传统修复方法进行修补。主要观察指标:3组分别于术后1,3,6个月时取材行光镜检查及抗拉力强度测定。结果:全部动物无伤口裂开、无腹壁疝形成,脱细胞真皮基质修补组脏面未与内脏粘连,聚丙烯补片修补组均与内脏粘连。组织切片苏木精-伊红染色检查表明脱细胞真皮基质较聚丙烯补片、传统修补更有利于成纤维细胞及血管形成,6个月内脱细胞真皮基质可逐渐降解替代;6个月时聚丙烯补片仍有炎症反应,表现了长期的异物影响;传统修补只是肌肉之间简单的瘢痕愈合,增殖较少,生长较慢。抗拉力试验结果提示在3个阶段除6个月时脱细胞真皮基质修补处与聚丙烯补片修补处抗拉力强度相等外,余均提示在抗拉力强度上脱细胞真皮基质修补处聚丙烯补片修补处传统方法修补处。结论:脱细胞真皮基质修复战伤腹壁缺损的效果等同于聚丙烯补片,均优于传统修复方法,安全性优于聚丙烯补片。
[Abstract]:Background: in recent years, with the advent of various new synthetic repair materials, the application of these materials to repair the abdominal wall defects caused by disease has also achieved good results. Objective: to compare the efficacy and safety of acellular dermal matrix, polypropylene patch and traditional methods in repairing abdominal wall defect after war injury. Completed in the Laboratory of Animal Experimental surgery, Xijing Hospital and Tangdu Hospital, 4th military Medical University of the PLA in 2008-01 / 08. Materials: acellular dermal matrix provided by Yantai Zhenghai Biotechnology Co., Ltd. Methods Twenty seven adult mongrel dogs were randomly divided into 3 groups, which were treated with acellular dermal matrix and polypropylene patch. The main outcome measures of group 1: 3 were taken at 1: 3 and 6 months after operation for light microscope examination and tensile strength measurement. Results: all animals had no wound rupture, no abdominal wall hernia, and no abdominal wall hernia. In the acellular dermal matrix repair group, visceral adhesion was not found in the visceral surface, but in the polypropylene patch repair group, the visceral adhesion was found in the polypropylene patch repair group. The histopathological examination of hematoxylin-eosin staining showed that the acellular dermal matrix was higher than that of the polypropylene patch. Traditional repair is more favorable to fibroblast and angiogenesis, acellular dermal matrix can be gradually degraded and replaced within 6 months, polypropylene patch still has inflammatory reaction at 6 months, showing long-term foreign body effect. The results of tensile strength test showed that the tensile strength of acellular dermal matrix repair was equal to that of polypropylene patch at 6 months, and the tensile strength of acellular dermal matrix repair was equal to that of polypropylene patch. Conclusion: acellular dermal matrix is as effective as polypropylene patch in repairing abdominal wall defect after war injury, and it is superior to traditional repair method. The safety is superior to that of polypropylene patch.
【作者单位】：解放军第四军医大学唐都医院普通外科;
【分类号】：R82

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