新兵军事体能训练对肌酸激酶和转氨酶的影响

发布时间：2018-04-14 08:12

本文选题：肌酸激酶 + 转氨酶　；参考：《军事医学》2017年02期

【摘要】：目的通过对新入伍战士进行军事体能训练(MPT)前后肌酸激酶(CK)、肝功能(LF)和肾功(RF)等生化指标的随访研究,早期预警MPT过程中可能出现的运动性横纹肌溶解(ER)和肾功能衰竭(RFF)等严重并发症,从而尽最大可能减少训练伤痛,提高训练质量。方法某陆军新兵174名,均为男性,平均年龄(18.46±1.17)岁,分别于MPT前(D0),MPT第4天(D4)、第18天(D18)、第39天(D39)和MPT结束后第7天(D67)5个时间点采血5次,化验其CK、LF和RF等指标的变化。结果 174名新兵在D0、D4、D18、D39和D67的CK平均值分别为370、2617、657、536和212U/L(P0.01);天冬氨酸转氨酶(AST)的平均值分别为24、69、35、34和24 U/L(P0.01);丙氨酸转氨酶(ALT)的平均值分别为18、30、26、25和22 U/L(P0.01)。在D4时间点,CK的峰值为17214 U/L,升高率为100%,9.2%的新兵升高50倍正常值上限(upper limit normal,ULN);AST的峰值为387 U/L,升高率为47.7%,16.7%的新兵升高3 ULN;ALT的峰值为104 U/L,升高率为18.4%,但无新兵ALT升高3 ULN。MPT期间未见胆红素和肾功能变化。CK升高与AST和ALT升高呈正相关,相关系数分别是0.94和0.68。MPT期间未发现士兵出现ER和RFF。结论新兵在MPT期间会出现CK、AST和ALT的升高,以早期最为明显,升高程度CKASTALT,CK的升高与AST和ALT密切相关。
[Abstract]:Objective to study the biochemical indexes of creatine kinase CKD, liver function LFand and renal function of newly enlisted soldiers before and after MPT training.Early warning of serious complications such as motor rhabdomyolysis and renal failure may occur in the process of MPT so as to minimize the injury and improve the training quality as far as possible.Methods 174 recruits, all male, were aged 18.46 卤1.17 years. Their blood samples were collected at 5 time points before MPT, including D4, D18, D39) and D67 (7 days after MPT), respectively. The changes of CKLF and RF were analyzed. The results were as follows: (1) the mean age was 18.46 卤1.17 years (P < 0.05), and the mean age was (18.46 卤1.17) years old. The changes of CKLF and RF were measured at 5 time points before MPT, on the 18th day, on the 18th day, on the 39th day, and on the 7th day after MPT.Results the average values of CK, aspartate transaminase (AST) and alanine aminotransferase (alt) in 174 recruits were 3702617657536 and 212U / L respectively (P 0.01) and 24 U / L P 0.01, respectively, and the mean values of alanine aminotransferase (alt) were 1830U / 2625 and 22 U / L P 0.01, respectively.At D4 time, the peak value of CK was 17214 UL, and the increase rate was 100%. The upper upper limit normal value was 50 times higher than normal value. The peak value of ULNalt was 387UL, the increase rate was 47.7U / L, the peak value of 3ULNalt was 104UL, and the increase rate was 18.4U / L, but no recruits had ALT increased 3 ULN.MPT.There was no positive correlation between the increase of bilirubin and renal function. CK and the increase of AST and ALT.The correlation coefficients were 0. 94 and 0. 94 and no ER and RFF were found during 0.68.MPT.Conclusion the increase of CK AST and ALT in recruits during MPT is most obvious in the early stage. The elevation of CK in CKAST LTN is closely related to AST and ALT.
【作者单位】：解放军302医院干部医疗保健中心暨军人肝病中心;解放军66176部队卫生队;解放军302医院临床检验中心;
【基金】：全军医学科技十二五资助项目(424120307)
【分类号】：R821.2

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