模拟失重对大鼠下颌骨、腰椎和股骨组织结构的影响

发布时间：2018-04-15 13:19

本文选题：失重模拟 + 下颌骨　；参考：《航天医学与医学工程》2005年03期

【摘要】：目的了解模拟失重对大鼠不同部位骨骼组织结构的影响。方法25只大鼠,随机分为2组:对照组(n=10)和头低位30°尾吊组(n=15)。实验第28天时,取2组动物的下颌骨、腰椎和股骨。观察指标为下颌骨髁状突、下颌骨体磨牙区和前磨牙区、第一腰椎、股骨头、股骨中段和股骨髁部的组织学结构。结果对照组和尾吊组髁状突骨形态学结构无明显差别,只是尾吊组骨小梁之间的交织程度增加。2组下颌骨体部骨质均较致密,骨质结构、牙周膜厚度无明显差别。与对照组比,尾吊组前磨牙区骨板排列规则,成熟程度比磨牙区高;尾吊组磨牙区骨增生线排列紊乱不规则,示骨质改建较多。与对照组比,尾吊组股骨、腰椎骨小梁成分减少,粗细不均匀,小梁之间交织连接程度差。结论4周模拟失重可以引起脊椎骨股骨的骨质疏松,但是对下颌骨没有明显的影响。
[Abstract]:Objective to investigate the effects of simulated weightlessness on bone structure in different parts of rats.Methods Twenty-five rats were randomly divided into two groups: control group (n = 10) and head-low 30 掳tail suspension group (n = 15).On the 28th day, mandible, lumbar vertebrae and femur of the two groups were taken.The histological structure of mandibular condyle, mandibular molar and premolar region, first lumbar vertebra, femoral head, middle femur and femoral condyle were observed.Results there was no significant difference in condylar bone morphology between the control group and the tail suspension group, but the interwoven degree between trabeculae and trabeculae in the tail suspension group was increased. 2. There was no significant difference in bone structure and periodontal membrane thickness between the two groups.Compared with the control group, the bone plate arrangement of the premolar region in the tail suspension group was regular, and the degree of maturity was higher than that in the molar region, while the bone hyperplasia line in the molar area in the tail suspension group was irregular, indicating more bone remodeling.Compared with the control group, the trabecular composition of lumbar vertebrae in the tail suspension group decreased, the thickness was not uniform, and the degree of interwoven connection between trabeculae was poor.Conclusion 4-week simulated weightlessness can cause osteoporosis in the vertebrae femur, but has no significant effect on the mandible.
【作者单位】：解放军总医院口腔科解放军总医院口腔科解放军总医院口腔科解放军总医院口腔科
【基金】：全军医学科研“十五”计划青年基金课题(01Q061)
【分类号】：R852.22

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