维拉帕米和尼莫地平对硫芥中毒大鼠血清NO的影响

发布时间：2018-04-19 11:30

本文选题：维拉帕米 + 尼莫地平　；参考：《中国公共卫生》2002年09期

【摘要】：目的　研究维拉帕米、尼莫地平这两种钙离子通道阻滞剂对硫芥中毒大鼠血清中一氧化氮水平的影响 ,并初步探讨其机制。方法　将硫芥染毒的大鼠分别用螺旋藻多糖、谷胱甘肽、维拉帕米、尼莫地平、以维拉帕米为主的复方一、以维拉帕米为主的复方二、以尼莫地平为主的复方三和以尼莫地平为主的复方四救治 ,并设立阴性对照组和阳性对照组。结果　阴性对照组的一氧化氮水平和维拉帕米、尼莫地平、复方一、复方二、复方三和复方四治疗组一致 ;阳性对照组的一氧化氮水平和谷胱甘肽治疗组一致 ;饮用PS治疗组的一氧化氮水平介于阴、阳性对照组之间。结论　维拉帕米、尼莫地平能够拮抗硫芥中毒所致的高一氧化氮水平 ,其机制可能与维拉帕米和尼莫地平阻滞Ca2 + 进入细胞有关
[Abstract]:Objective to study the effects of verapamil and nimodipine on serum nitric oxide levels in rats with sulfur mustard poisoning.Methods the rats exposed to sulfur mustard were treated with spirulina polysaccharide, glutathione, verapamil, nimodipine, verapamil and verapamil respectively.Compound San of nimodipine and compound four of Nimodipine were treated, and negative control group and positive control group were set up.Results the level of nitric oxide in the negative control group was consistent with that in the verapamil, nimodipine, compound 1, compound 2, compound 3 and compound 4 groups, and the level of no in the positive control group was the same as that in the glutathione treatment group.The level of nitric oxide in PS treatment group was between negative and positive control group.Conclusion verapamil and nimodipine can antagonize the high nitric oxide level induced by sulfur mustard poisoning, and the mechanism may be related to the blocking of Ca2 entry into cells by verapamil and nimodipine.
【作者单位】：第二军医大学南京军医学院预防医学教研室第二军医大学南京军医学院预防医学教研室第二军医大学南京军医学院预防医学教研室第二军医大学防化医学教研室
【基金】：“九·五”军队基金课题 (96L0 37)
【分类号】：R82

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