头低位卧床模拟失重对认知功能的影响及中药干预效果

发布时间：2018-05-04 01:07

本文选题：模拟失重 + 头低位卧床　；参考：《航天医学与医学工程》2014年02期

【摘要】：目的观察模拟失重对脑认知功能的影响及中药的干预效果。方法 16名志愿者,-6°头低位卧床(head-down bed rest,HDBR)3周前和卧床结束当天起床前各进行一次fMRI实验,包括中性、冲突两种任务模式和事件相关设计。随机分对照组(8人)、用药组(8人),用药组卧床期间服用自制中药制剂200 mL/d,3周,对照组服用等量安慰剂。结果两组模拟失重前:前扣带回、额叶和丘脑出现显著的激活。模拟失重后(对照组):额叶、前扣带回激活区的范围和信号强度较卧床前显著减少,丘脑激活消失。模拟失重后(用药组):前扣带回出现了显著的激活区,丘脑可见较显著的激活区,右侧额叶额中回小范围激活区。脑激活区范围和信号强度接近模拟失重前状态。结论模拟失重状态对认知功能有明显的影响,中药可以增强相关脑区对认知功能的调控作用。
[Abstract]:Objective to observe the effect of simulated weightlessness on brain cognitive function and the intervention effect of traditional Chinese medicine. Methods Sixteen volunteers with head-down bed before 6 掳head-down bed rest were tested with fMRI three weeks ago and one on the same day before bed rest, including neutral, conflicting task mode and event-related design. They were randomly divided into two groups: control group (n = 8) and control group (n = 8). During bed rest, the control group was given 200 mL / d ~ (-1) of traditional Chinese medicine for 3 weeks, while the control group was given the same amount of placebo. Results before simulated weightlessness, the anterior cingulate gyrus, frontal lobe and thalamus were significantly activated. After simulated weightlessness (control group: frontal lobe, anterior cingulate gyrus activation area range and signal intensity were significantly reduced compared with those before bed rest, thalamus activation disappeared. After simulated weightlessness, the anterior cingulate gyrus showed a significant activation area, the thalamus showed a more significant activation area, and the middle frontal gyrus of the right frontal lobe showed a small area of activation. The area and signal intensity of brain activation area are close to the state of simulated weightlessness. Conclusion simulated weightlessness has a significant effect on cognitive function. Chinese herbal medicine can enhance the regulation of cognitive function in related brain regions.
【作者单位】：解放军306医院磁共振室暨国家"认知科学与学习"重点实验室脑功能成像中心;中国航天员科研训练中心;
【基金】：国家重点基础研究发展计划(973计划,2012CB720704)
【分类号】：R85

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