高频正弦波振动对尾吊大鼠比目鱼肌H反射变化的改善作用

发布时间：2018-05-04 09:51

本文选题：失重模拟 + 高频正弦波振动　；参考：《航天医学与医学工程》2008年02期

【摘要】：目的本研究旨在进一步观察尾吊大鼠与肌梭兴奋性传入有关的α运动神经元的兴奋性的变化,并探讨高频正弦波振动比目鱼肌能否对这种兴奋性的变化产生影响。方法用大鼠尾部悬吊法建立模拟失重模型。对比目鱼肌施加机械正弦波振动(100Hz,0.3mm)。电刺激坐骨神经,同时记录比目鱼肌肌电图。结果尾吊和高频正弦波振动均不影响H反射幅值在刺激强度增加时的变化趋势。尾吊14d后,大鼠最大运动反应(Mmax)和Hmax与Mmax之比(Hmax/Mmax)明显减小,而在尾吊期间给予高频振动后二者没有显著性差异。结论模拟失重状态下肌梭的传入冲动减少可引起大鼠脊髓运动神经元兴奋性降低。高频正弦波振动比目鱼肌可以提高模拟失重条件下脊髓α运动神经元的兴奋性。
[Abstract]:Objective to further investigate the changes of the excitability of 伪 -motor neurons associated with spindle excitatory afferent in tail-suspended rats, and to explore whether the high-frequency sine wave vibration of soleus muscle can affect the change of this excitability. Methods the model of simulated weightlessness was established by tail suspension of rats. The mechanical sine wave vibration of 100 Hz ~ 0.3mm ~ (-1) was applied to the soleus muscle. Electric stimulation of sciatic nerve and recording of soleus muscle electromyography. Results both tail suspension and high frequency sinusoidal vibration did not affect the trend of H reflection amplitude when the intensity of stimulus increased. After 14 days of tail suspension, the maximal motor response (Mmaxmax) and the ratio of Hmax to Mmax (Hmax / Mmax) were significantly decreased, but there was no significant difference between them after high frequency vibration during tail suspension. Conclusion the decrease of afferent impulse of muscle spindle in simulated weightlessness can decrease the excitability of spinal motoneurons in rats. High frequency sine wave vibration of soleus muscle can improve the excitability of spinal cord 伪 motor neurons under simulated weightlessness.
【作者单位】：西安交通大学医学院生理学教研室西安交通大学医学院生理学教研室西安交通大学医学院生理学教研室西安交通大学医学院生理学教研室西安交通大学医学院生理学教研室
【基金】：国家自然科学基金资助(30070830)
【分类号】：R85

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