应力环境对大鼠股骨生长与重建和力学性能的影响

发布时间：2018-05-05 10:14

本文选题：应力环境 + 生长与重建　；参考：《中国生物医学工程学报》2006年01期

【摘要】：通过创建一种新的动物模型,研究应力环境对生长期大鼠股骨生长与重建,以及对其力学性能的影响,并探讨其作用机理。切断6周大SD大鼠右后肢的坐骨神经,致使其右后肢残废,为废用组;左后肢过度负重,为过载组;正常大鼠为对照组。每天早午晚鼓励动物运动半小时,4周后结束实验观测。测量股骨中段的宏观几何学参数、物理学参数和生物力学参数。实验发现:与对照组相比,实验组股骨的若干几何及物理参数发生了明显变化,表明应力环境可以改变活骨组织的成份和结构并逐渐改变其力学性能。实验结果表明,本研究提出的实验模型实用且可靠。
[Abstract]:By creating a new animal model, the effects of stress environment on the growth and reconstruction of femur and its mechanical properties in growing rats were studied, and the mechanism of its action was discussed. The sciatic nerve of the right hind limb of SD rats was cut off for 6 weeks, the right hind limb was disabled, the left hind limb was overloaded, and the normal rats were the control group. Animals were encouraged to exercise for half an hour every morning, afternoon and night. The macroscopic geometric parameters, physical parameters and biomechanical parameters of the middle femur were measured. It was found that the geometric and physical parameters of femur in the experimental group changed obviously compared with the control group, which indicated that the stress environment could change the composition and structure of the living bone tissue and gradually change the mechanical properties of the living bone tissue. The experimental results show that the proposed experimental model is practical and reliable.
【作者单位】：大连医科大学第二临床学院骨科大连理工大学工程力学系工业装备结构分析国家重点实验室大连理工大学工程力学系工业装备结构分析国家重点实验室大连理工大学工程力学系工业装备结构分析国家重点实验室大连医科大学第二临床学院骨科大连医科大学第二临床学院骨科大连医科大学第二临床学院骨科
【基金】：国家自然科学基金资助项目(10472025) 辽宁省自然科学基金资助项目(20032109)
【分类号】：R85

【相似文献】