基于fALFF及ReHo法观察低氧暴露后飞行员静息态脑功能的变化

发布时间：2018-06-02 07:59

本文选题：缺氧 + 静息态脑功能　；参考：《解放军医学杂志》2015年06期

【摘要】：目的探讨静息态功能核磁共振成像(rs-fMRI)分数低频振幅(fALFF)和局域一致性(ReHo)方法在低氧暴露后飞行员静息态脑功能评价中的应用价值。方法 30名男性健康飞行员先后接受常压常氧、氧浓度为14.5%的常压低氧暴露,采用f ALFF及ReHo方法对受试者低氧暴露前后rs-f MRI数据进行对比分析,观察低氧暴露之后f ALFF及ReHo值发生变化的脑区。结果低氧暴露后,30名飞行员脉搏、血氧饱和度分别为64.0±10.6次/min、92.4%±3.9%,较暴露前(分别为71.4±10.9次/min、96.3%±1.3%)有所下降(P0.05)。静息态下,30名飞行员低氧暴露后f ALFF值降低的脑区包括双侧颞上回、右侧额上回,f ALFF值增高的脑区为左侧楔前叶,Re Ho值降低的脑区为右侧额上回(P0.05),未发现Re Ho值增加的脑区。结论低氧暴露对静息态下某些脑区功能活动有明显影响,可能与认知功能变化有关。
[Abstract]:Objective to evaluate the application of rest functional magnetic resonance imaging (FMRI) fractional low frequency amplitude fALFFFF) and local consistency ReHoC in the evaluation of resting brain function of pilots after hypoxic exposure. Methods 30 healthy male pilots were exposed to normobaric normoxic oxygen with an oxygen concentration of 14.5%. Rs-f MRI data before and after hypoxic exposure were analyzed by f ALFF and ReHo methods. The changes of f ALFF and ReHo were observed after hypoxia exposure. Results the pulse rate and blood oxygen saturation of 30 pilots after hypoxic exposure were 64.0 卤10.6 / min 92.4% 卤3.9respectively, which were lower than those before exposure (71.4 卤10.9 / min 96.3% 卤1.3%). In 30 pilots with resting hypoxia, the decreased f ALFF value included the bilateral superior temporal gyrus, and the area where the right superior frontal gyrus increased its ALFF value was the right superior frontal gyrus where the re Ho value decreased in the right superior frontal gyrus (P0.05). No increase in re Ho value was found in the right superior frontal gyrus. Conclusion hypoxic exposure has a significant effect on the functional activities of some brain regions under resting state, which may be related to the changes of cognitive function.
【作者单位】：空军总医院磁共振科;北京大学生物医学工程系;空军总医院空勤科;
【分类号】：R85

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