模拟失重对新西兰兔股静脉压力-容积关系的影响

发布时间：2018-06-06 20:10

本文选题：失重模拟 + 顺应性　；参考：《航天医学与医学工程》2002年06期

【摘要】：目的观察模拟失重对兔股静脉压力 -容积关系的影响及静脉壁显微结构的变化。方法采用头低位 ( - 2 0°)倾斜的方法作为模拟失重家兔模型。 2 4只雄性健康新西兰兔 ,随机分为对照组、模拟失重 2 1d组和模拟失重 1 0d组 ,每组 8只。进行股静脉的压力 -容积 (P V)关系测试 ,并观察血管壁的显微结构。结果模拟失重后股静脉P V曲线向容积变化比增大的方向移动 ,模拟失重 2 1d组较 1 0d组移动更明显。分别于加、卸载测试时拟合出的模拟失重 2 1d组P V二次抛物线方程式系数B1 、B2 值均显著高于对照组及模拟失重 1 0d组 (P 0 .0 1 ) ,模拟失重 1 0d组的B1、B2值和对照组相比有增加的趋势。组织学观察表明 ,模拟失重组股静脉内皮细胞呈立方或矮柱状并有细胞脱落 ,平滑肌层变薄等变化。结论模拟失重后股静脉顺应性增加 ,2 1d组较 1 0d组增加明显 ,同时股静脉管壁结构也发生明显改变
[Abstract]:Objective To observe the effect of simulated weightlessness on the pressure volume relationship of femoral vein and the changes of the microstructure of the venous wall. Methods using the head low (- 20 degree) tilt method as a simulated weightless rabbit model, 24 male healthy New Zealand rabbits were randomly divided into the control group, and the simulated weightlessness 2 1D groups and the simulated weight loss 1 0d groups were carried out in each group of 8. The pressure volume (P V) relationship of the femoral vein was tested and the microstructure of the blood vessel wall was observed. The result was that the P V curve of the femoral vein moved to the direction of volume, and the simulated weightlessness 2 1D group was more obvious than that of the 1 0d group. In addition, the simulated weight loss 2 1D group P V two parabolic equations were fitted respectively. B1, B2 value was significantly higher than the control group and simulated weight loss 1 0d group (P 0.01), simulated weightlessness 1 0d group B1, B2 value compared with the control group has an increase trend. Histological observation showed that the simulated weightless femoral vein endothelial cells were cubic or short column like, cell fall, smooth muscle layer thinning and other changes. Conclusion the simulated weightlessness after the strands of the femoral static The pulse compliance increased significantly in the 2 1D group compared with that in the 1 0d group, and the structure of the femoral vein wall also changed significantly.
【作者单位】：第四军医大学航空航天医学系第四军医大学航空航天医学系第四军医大学航空航天医学系第四军医大学航空航天医学系第四军医大学西京医院骨科第四军医大学航空航天医学系
【基金】：国家自然科学基金 (3 0 0 0 0 197)
【分类号】：R85

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