腹部开放伤合并海水浸泡致犬急性心力衰竭的病理生理变化

发布时间：2018-06-26 20:56

本文选题：腹部开放伤 + 海水　；参考：《第二军医大学学报》2009年11期

【摘要】：目的:观察犬腹部开放性损伤经海水浸泡后致急性心力衰竭的一系列病理生理变化。方法:以成年杂种犬为实验对象,随机分为腹部伤+海水浸泡组(A组,n=8)和单纯腹部伤组(B组,n=8)。观察实验动物致腹部开放性损伤前、后,经海水浸泡2 h及打捞出水后不同时间点心律、心率、收缩压、舒张压、平均动脉压、肺动脉楔压、中心静脉压、心输出量、心脏指数、肾素、脑钠肽等相关指标及病死率。并于致伤前及致伤后4 h行超声心动图,测定左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)、每搏输出量(SV)、左室射血分数(LVEF)。结果:致伤后0.5 h至观察终点,A组犬平均动脉压均明显下降(P0.05,P0.01),B组犬平均动脉压无明显变化。致伤后A组犬肺动脉楔压显著上升,其中心静脉压、心输出量、心脏指数逐渐下降,打捞出水后仍继续下降(P0.05,P0.01),与B组比较有显著差异(P0.05,P0.01);B组犬腹部致伤前后其肺动脉楔压、中心静脉压、心输出量、心脏指数无明显差异;致伤后A组犬血肾素、脑钠肽水平明显升高(P0.05,P0.01),B组犬血肾素、脑钠肽水平无明显变化。结论:腹部开放伤合并海水浸泡致犬急性心力衰竭病理生理变化非常明显,为后续研究奠定了基础。
[Abstract]:Objective: to observe a series of pathophysiological changes of acute heart failure caused by open abdominal injury in dogs. Methods: adult mongrel dogs were randomly divided into two groups: group A (group A) and group B (group B). The cardiac rhythm, heart rate, systolic pressure, diastolic pressure, mean arterial pressure, pulmonary wedge pressure, central venous pressure and cardiac output were observed before and after abdominal open injury. Cardiac index, renin, brain natriuretic peptide and other related indicators and mortality. The left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), stroke volume (SV) and left ventricular ejection fraction (LVEF) were measured before and 4 hours after injury. Results: from 0.5 h after injury to the observed end point, the mean arterial pressure in group A was significantly decreased (P0.05, P0.01). There was no significant change in mean arterial pressure in group B. Pulmonary artery wedge pressure increased significantly in group A after injury, and the central venous pressure, cardiac output and cardiac index decreased gradually, and continued to decrease after salvage (P0.05, P0.01). There was a significant difference between group B and group B (P0.05, P0.01) in pulmonary artery wedge pressure before and after abdominal injury in group B, and the pulmonary artery wedge pressure in group B was significantly lower than that in group B before and after abdominal injury. There was no significant difference in central venous pressure, cardiac output and cardiac index, but the levels of renin and brain natriuretic peptide in group A were significantly higher than those in group B (P0.05, P0.01). There were no significant changes in serum renin and brain natriuretic peptide levels in group B. Conclusion: the pathophysiological changes of acute heart failure caused by open abdominal injury and seawater immersion are very obvious, which lays a foundation for further study.
【作者单位】：海军总医院心内科;
【基金】：海后司令部科研计划课题(04-3304)~~
【分类号】：R83

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