四种抗运动病药物的比较研究

发布时间：2018-09-17 12:51

【摘要】：目的 :筛选药效好、副作用小的抗运动病药物。方法 :通过文献资料分析 ,选取脑益嗪和多潘立酮、异丙嗪和麻黄素、茶苯海明与苯丙胺和生姜联合用药 ,以及盐酸苯环壬脂等 4组药物 ,以乳糖为安慰剂 ,用 Coriolis加速度耐力评价药效 ,用副作用症状、体征发生率评价副作用表现 ,用神经行为评价系统测试副作用对工作能力的影响。结果 :脑益嗪和多潘立酮联合用药的加速度耐力与异丙嗪和麻黄素联合用药相比无显著差异 (P0 .0 5 ) ,但显著高于其他各组 (P0 .0 5 )。异丙嗪和麻黄素联合用药的副作用 (嗜睡、头昏、疲乏、口干和心悸 )发生率高于其他各组 (P0 .0 1或 P0 .0 5 )。神经行为测试各指标的组间均无显著差异 (P0 .0 5 )。结论 :脑益嗪和多潘立酮联合用药的药效好 ,未发现副作用表现及对工作能力的影响。
[Abstract]:Objective: to screen anti-motor disease drugs with good efficacy and little side effects. Methods: according to the literature analysis, four groups of drugs, such as nouizine and domperidone, promethazine and ephedrine, tea phenylephrine combined with amphetamine and ginger, and benzylnonyl hydrochloride, were selected as placebo, and lactose was used as placebo. The Coriolis acceleration tolerance was used to evaluate the efficacy, the incidence of side effects and signs were used to evaluate the side effects, and the neurobehavioral evaluation system was used to test the effects of side effects on working ability. Results: compared with promethazine and ephedrine, there was no significant difference in acceleration tolerance (P0. 05), but it was significantly higher than other groups (P0. 05). The incidences of side effects (somnolence, dizziness, fatigue, dry mouth and palpitation) of promethazine combined with ephedrine were higher than those of other groups (P0. 01 or P0. 05). There was no significant difference among groups in neurobehavioral test (P0. 05). Conclusion: the combination of naphizine and domperidone is effective, no side effects and effects on working ability are found.
【作者单位】：第二军医大学海军医学系军队卫生学教研室!上海200433 海军医学研究所航海医学研究室第二军医大学海军医学系军队卫生学教研室!上海200433 第二军医大学海军医学系军队卫生学教研室!上海200433 海军医学研究所航海医学研究室第二军医大学海军医学系军队卫生学教研室!上海2004
【基金】：全军“九五”指令性课题!资助项目 (96 L 0 38)
【分类号】：R837

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